Example sentences for: orthology

How can you use “orthology” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In many cases a discrepancy between orthology bootstrap values and sequence similarity is caused by orthologs in only phylogenetically distant (relatively to the query sequence) species.

  • An indication of this problem (besides a discrepancy between orthology bootstrap values and sequence similarity) is the meeting of the following three conditions: A query sequence has (i) likely orthologs and (ii) likely subtree-neighbors in other species than the query itself, yet (iii) there is no significant overlap between the orthologs and the subtree-neighbors.

  • Careless use of orthology relationships without examining the tree itself can lead to incorrect annotations.

  • For some query sequences, the top orthology values are low.

  • Storm, Sonnhammer, and colleagues have recently developed similar ideas and procedures in a program called ORTHOSTRAPPER [ 44 45 ] . One distinction between the two approaches is that ORTHOSTRAPPER's orthology determination procedure does not employ a species tree for duplication inference; it uses a heuristic based on sequence similarity rather than a formally correct phylogenetic means of inferring orthology.


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