Words similar to orthology
Example sentences for: orthology
How can you use “orthology” in a sentence? Here are some example sentences to help you improve your vocabulary:
In many cases a discrepancy between orthology bootstrap values and sequence similarity is caused by orthologs in only phylogenetically distant (relatively to the query sequence) species.
Similarly to the issues described in the previous section, the detection of such examples is complicated by the fact that for many cases in which a discrepancy between orthology bootstrap values and sequence similarity exists, all sequences in the Pfam alignment appear to have to same function, the Pfam family is lineage specific, or the annotations are too poor/confusing to make any kind of inference.
For a given gene pair AB (A and B are separate genes and are encoded continuously on the chromosome) in the target genome, the presence of AB in a reference genome is recorded when we detect the presence of either an A'B' or a B'A' gene cluster, where gene A' is a homolog of gene A and gene B' is a homolog of gene B. There are many established methods for detecting homology or orthology, for example, membership in the same COG (Clusters of Orthologous Genes) [ 12].
Only two of the 560 protein-coding genes that show clear orthology between E. coli and Buchnera would have been removed (due to absence from both Vibrio cholerae and Yersinia pestis ). The two genes ( dnaC and dnaT ) are linked in both Buchnera and E. coli and were retained in the ancestor.
In light of the similarities of certain genes generated by CoreGenes, one may ponder their relationships upon further and closer inspection, given that the high BLAST scores between two genes do not always imply an orthologous relationship [ 30 ] . In other words, the complexity of these BLAST scores suggests that the user should perform rigorous phylogenetic analysis of each set of homologous genes to determine true orthology.
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