Example sentences for: orthology

How can you use “orthology” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, this solution (even if attractive from the point of view of classification) does not seem to be correct in light of the principle of orthology that underlies the COG system: it appears that, in both of the COGs involved, the fusion components and stand-alone proteins are bona fide orthologs, as judged by the high level of sequence conservation and by the fact that, in the majority of species involved, they are the only versions of this key enzyme.

  • Orthology was assessed using reciprocal BLAST searches of the public protein database; those sequences receiving high scores in each search were also analyzed phylogenetically to ensure orthology.

  • For a given gene pair AB (A and B are separate genes and are encoded continuously on the chromosome) in the target genome, the presence of AB in a reference genome is recorded when we detect the presence of either an A'B' or a B'A' gene cluster, where gene A' is a homolog of gene A and gene B' is a homolog of gene B. There are many established methods for detecting homology or orthology, for example, membership in the same COG (Clusters of Orthologous Genes) [ 12].

  • Data from the following species were assembled into presumptive orthology groups (hereafter, proteins) and aligned [ 36 ] : Aquifex aeolicus , Bacillus subtilis , Borrelia burgdorferi , Chlamydia trachomatis , Escherichia coli , Haemophilus influenzae , Helicobacter pylori, Mycobacterium tuberculosis, Mycoplasma genitalium, Mycoplasma pneumoniae , Rickettsia prowazekii, Synechocystis sp., and Treponema pallidum (Eubacteria), Archaeoglobus fulgidus, Methanobacterium thermoautotrophicum, Methanococcus jannaschii, Pyrococcus abyssi , and P. horikoshii (Archaebacteria: Euryarchaeota), and Arabidopsis thaliana, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Gallus gallus, Homo sapiens, Mus musculus, Oryza saticva, Plasmodium falciparum, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Trypanosoma sp. , and Xenopus laevis (Eukaryota).

  • Only two of the 560 protein-coding genes that show clear orthology between E. coli and Buchnera would have been removed (due to absence from both Vibrio cholerae and Yersinia pestis ). The two genes ( dnaC and dnaT ) are linked in both Buchnera and E. coli and were retained in the ancestor.


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