Words similar to orthologs
Example sentences for: orthologs
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Three obvious factors contribute to divergence of sequence in orthologs.
In an attempt to isolate the effect of duplication per se on purifying selection, we analyzed paralogs and orthologs that appeared to encode proteins with similar functions, namely secreted and membrane proteins that were identified by signal peptide and transmembrane helix prediction.
Further, transitive searches with the proteins detected in the above searches resulted in the identification of more divergent homologs, such as a protein termed the 'enterohemolysin associated protein' (EHAP1) from E. coli [ 19 ] and its orthologs in
The dephosphorylation of phosphoproteins is universally catalyzed by protein phosphatases that are classified into two major functional groups, protein tyrosine phosphatase (PTP) and protein serine/threonine phosphatase (PP) although enzymes with various degrees of dual-specificity are also encountered [ 1 2 3 4 5 ] . The majority of Ser/Thr phosphatases belong to three classical groups, namely PP1, PP2A, and PP2B (calcineurin), and possess similar primary structures in their catalytic cores [ 2 3 6 ] . PP1, in particular, exhibits an extremely high degree of sequence conservation through evolution, and its orthologs and isoforms are found in all eukaryotic cells [ 6 7 ] . In various organisms, PP1 regulates such diverse cellular processes as cell cycle progression, protein synthesis, carbohydrate metabolism, transcription, and neuronal signaling [ 3 7 ] , underscoring its profound importance in biology.
Nevertheless, comparison between these two bacteria showed no discernable correlation between the number of protein-protein interactions and the rates of substitution between orthologs, measured either directly or using the rank correlation approach (Figure 2band Table 1).
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