Words similar to oligodeoxyribonucleotide
- olig
- oligo
- oligo-
- oligocene
- oligodendrocytes
- oligodendroglial
- oligodeoxynucleotide
- oligodeoxynucleotide-mediated
- oligodeoxynucleotides
- oligodeoxyribonucleotide
- oligodeoxyribonucleotides
- oligofectamine
- oligolabeled
- oligomer
- oligomeric
- oligomerization
- oligomers
- oligonucleosomal
- oligonucleotide
- oligonucleotide-directed
Example sentences for: oligodeoxyribonucleotide
How can you use “oligodeoxyribonucleotide” in a sentence? Here are some example sentences to help you improve your vocabulary:
Much debate exists regarding the optimal oligodeoxyribonucleotide probe length.
The specificity on the CodeLink platform was previously demonstrated to result in less than 5% of the initial signal being retained when a 3-base mismatch is present in the middle of the 30-mer oligodeoxyribonucleotide probe [ 10 ] . We used this information to test whether the DNA:RNA duplex formation is affected by the probe's attachment to the DNA microarray surface and to determine how much of the probe is accessible for hybridization.
The strong correlation in the array and solution data in Figure 1Bdemonstrate that the mismatches at the 3' end of the oligodeoxyribonucleotide did not destabilize the duplex significantly, explaining the lack of a decrease in the signal intensity of these mismatches compared to the perfect match.
Moreover, a recent study found that both cDNA and oligodeoxyribonucleotide arrays underestimated the relative changes in mRNA expression between experimental and control samples, as determined by quantitative reverse transcriptase polymerase chain reaction [ 29 ] . This underestimation (or ratio compression) increased as the relative change increased, consistent with our observations (Figure 4B).
For example, oligodeoxyribonucleotide probes can be covalently attached to a surface [ 10 ] , synthesized in situ [ 11 12 13 ] , or retained via electrostatic interactions with a positively charged surface [ 14 ] . A recent study examining the effect of mismatches along the length of in situ synthesized 60 mer oligodeoxyribonucleotides demonstrated a lack of an effect of mismatches for the first ten to fifteen bases at the 3' (surface) end of the oligodeoxyribonucleotide, suggesting that these bases may not be accessible during the hybridization reaction [ 12 ] . Other problems may exist when oligodeoxyribonucleotides are adsorbed to a positively-charged surface.
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