Words similar to oligomerization
Example sentences for: oligomerization
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The initial step of the insertion can proceed in the presence of either Mg.ATP or a non-hydrolyzable ATP-analog and involves oligomerization of the BchD and BchI subunits to form an oligomeric ring of AAA protomers that resembles the ring structure of NSF and other AAA proteins [ 14 32 ] . The second step of the insertion involves an obligatory hydrolysis of ATP that is tightly coupled with the transfer of the chelated Mg 2+to the protoporphyrin ring by BchH [ 49 ] . Although the details differ from midasin, particularly with respect to the subunit composition of the AAA ring, this chelation reaction provides a structural model suggesting that the function of the midasin M-domain may be to regulate the ATPase activity of the AAA protomers in the pseudo-hexameric ring and thus couple ATP hydrolysis to the binding of a protein ligand at the MIDAS site.
One involved identification of a non-peptide activator of the granulocyte colony-stimulating factor (GCSF) pathway that appeared to act via receptor oligomerization [ 18 ] . Another report described a small-molecule activator of the insulin-signaling pathway that also acts at the level of the receptor [ 19 ] .
This observation is consistent with a report of BLM oligomerization [ 31].
Coiled-coil domains are protein oligomerization motifs, which consist of two or more alpha helices that twist around one another to form a supercoil [ 1 ] . Peptides with the capacity to form coiled coils are characterized by a heptad repeat pattern in which residues in the first and fourth position are hydrophobic, and residues in the fifth and seventh position are predominantly charged or polar.
The activated integrins may then undergo clustering whereby the transmembrane domain of each type of subunit (the α or β) interacts with itself—called homotypic oligomerization of the transmembrane domains (Figure 1) (Li et al.
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