Words similar to nucleophosmin
Example sentences for: nucleophosmin
How can you use “nucleophosmin” in a sentence? Here are some example sentences to help you improve your vocabulary:
It will be important in future work to refine these results and test, for example, whether NPM3 may have chromatin or ribosome assembly functions that are similar or complementary to nucleoplasmin or nucleophosmin, or whether it may have completely independent functions.
The striking similarities in amino acid sequence and domain structure between NPM3 and its chaperone relatives, nucleophosmin and nucleoplasmin, together with abundant expression levels and nuclear localization, strongly suggests that NPM3 shares fundamental nuclear chaperone functions with these proteins.
Multiple phosphorylation sites and nuclear localization signals, or the ability to bind proteins with such signals, are also characteristics of nucleophosmin and nucleoplasmin [ 16 27 28 29 ] . When the functions of NPM3 are elucidated, it will be of interest to determine the contribution of phosphorylation to these activities, since the functions of both nucleoplasmin and nucleophosmin are regulated by phosphorylation, which is extensive in both proteins [ 7 17 ] ).
The N-terminal core region of high similarity between family members correlates to a region in nucleophosmin/B23 that has been shown to be involved in oligomerization as well as chaperone activity [ 44 ] . A central portion between nucleophosmin's two acidic domains is required for ribonuclease activity [ 44 ] ; this region does not have a corresponding domain in either NPM3 or nucleoplasmin, suggesting that these proteins would lack such activity.
Indeed, NO29, a Xenopus protein with significant similarity to NPM3, is found to associate with NO38, the Xenopus ortholog of mammalian nucleophosmin [ 43 ] .
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