Words similar to nucleophosmin
Example sentences for: nucleophosmin
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Some of these activities include nucleic acid binding [ 11 ] , ribonuclease activity (for processing preribosomal RNA) [ 12 ] and association with maturing preribosomal ribonucleoprotein particles [ 13 14 ] . It may also be involved in the transport of ribosomal or other nucleosomal proteins across the nuclear membrane, as it is known to shuttle between the cytoplasm and nucleus and to stimulate the nuclear importation of proteins [ 15 16 ] . Nucleophosmin also appears to be intimately involved in centrosome duplication.
All of the nucleophosmin and nucleoplasmin homologs that have been studied to date are localized in the nucleus.
It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .
Indeed, NO29, a Xenopus protein with significant similarity to NPM3, is found to associate with NO38, the Xenopus ortholog of mammalian nucleophosmin [ 43 ] .
An amino acid comparison of NPM3 with these other members of the nucleophosmin/nucleoplasmin family from various metazoans reveals extensive sequence identities and similarities throughout all of NPM3 except the C-terminal 16 residues (Figure 3).
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