Words similar to nucleoplasmin
Example sentences for: nucleoplasmin
How can you use “nucleoplasmin” in a sentence? Here are some example sentences to help you improve your vocabulary:
We previously discovered and initially characterized a novel member of this family in the mouse, namely nucleophosmin/nucleoplasmin 3 ( Npm3 ). To identify the human ortholog of Npm3 and begin its characterization, we have cloned a human NPM3 cDNA, determined its genomic structure and relationship to other family members and show its expression in multiple tissues and subcellular localization in the nucleus.
All of the nucleophosmin and nucleoplasmin homologs that have been studied to date are localized in the nucleus.
This sequence is the likely nuclear localization signal (NLS) for these proteins [ 15 ] , similar to the bipartite NLS found in nucleoplasmin [ 36 ] . The one exception is the Langerhans cell protein-1 (LCP1)/KIAA0737 pair, which lacks the second basic residue of the motif.
In concert with the unrelated acidic protein N1/N2, which binds histones H3 and H4, they act together and with other factors to assemble nucleosomes [ 2 3 ] . In addition to assembly, nucleoplasmin and other proteins are involved in the chromatin remodeling and nucleosome disassembly that occurs, for example, during transcription to allow the access of transcription factors to nucleosomal DNA [ 4 ] . Another major function of nucleoplasmin is the decondensation of sperm chromatin at fertilization.
The N-terminal core region of high similarity between family members correlates to a region in nucleophosmin/B23 that has been shown to be involved in oligomerization as well as chaperone activity [ 44 ] . A central portion between nucleophosmin's two acidic domains is required for ribonuclease activity [ 44 ] ; this region does not have a corresponding domain in either NPM3 or nucleoplasmin, suggesting that these proteins would lack such activity.
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