Words similar to nucleoplasmin
Example sentences for: nucleoplasmin
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This sequence is the likely nuclear localization signal (NLS) for these proteins [ 15 ] , similar to the bipartite NLS found in nucleoplasmin [ 36 ] . The one exception is the Langerhans cell protein-1 (LCP1)/KIAA0737 pair, which lacks the second basic residue of the motif.
In this case, nucleoplasmin acts to exchange the sperm specific basic proteins, which allow the dense packing of DNA in sperm, with the histones H2A and H2B, thus effecting chromatin decondensation [ 5 6 ] . Phosphorylation of nucleoplasmin appears to be important in regulating this activity, as heavily phosphorylated nucleoplasmin is significantly more active [ 7 ] .
It will be important in future work to refine these results and test, for example, whether NPM3 may have chromatin or ribosome assembly functions that are similar or complementary to nucleoplasmin or nucleophosmin, or whether it may have completely independent functions.
A nucleic acid binding domain in the C-terminus of nucleophosmin is also lacking in NPM3 and nucleoplasmin, but the known functions of nucleoplasmin in nucleosome assembly and sperm decondensation suggest that this protein, and possibly NPM3, can accomplish intermolecular reactions involving nucleic acids in other ways, perhaps by associating with other proteins that have this binding activity.
An amino acid comparison of NPM3 with these other members of the nucleophosmin/nucleoplasmin family from various metazoans reveals extensive sequence identities and similarities throughout all of NPM3 except the C-terminal 16 residues (Figure 3).
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