Example sentences for: nucleophilic

How can you use “nucleophilic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Tumor suppression by Fhit is not destroyed by mutation of the nucleophilic His96 to Asn, a mutation that specifically reduces k cat [ 2 12 ] . Thus, evidence suggests that the proapoptotic function of Fhit depends on formation of an E-S complex.

  • In the first step of splicing, there is a nucleophilic attack by the branch-point residue on the nucleotide at position 1 of the intron, resulting in a lariat structure with the intron remaining attached to the 3' exon.

  • This reduction was active-site dependent: adding back multicopy HNT2 with the nucleophilic histidine replaced by alanine or aspartate reduced dinucleoside polyphosphate levels less than two-fold.

  • Residue E109 has been shown to render indole more nucleophilic via proton abstraction from N1 [ 23].

  • The final step involved a nucleophilic substitution of the 2-chloro group by piperazine at high temperatures.


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