Words similar to mhck-a

Example sentences for: mhck-a

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MHCK-C differs from MHCK-A and MHCK-B in that it lacks any significant amino-terminal domain upstream of the catalytic domain; conserved catalytic domain residues are present within approximately 30 residues of the methionine start codon of MHCK-C (Figure 1).
This model is consistent with the recent report that MHCK-A displays enrichment into anterior F-actin-rich protrusions of polarized cells during chemotaxis, and into phagocytic and macropinocytotic extensions [ 23 ] . The polar localization of MHCK-A would be consistent with the long-standing "polar relaxation" model for cytoskeletal reorganization during cytokinesis [ 33 ] . MHCK-A may represent a factor that contributes to polar relaxation in this system via polar disassembly of myosin II filaments.
Using epi-fluorescence microscopy, we observe strikingly different patterns of dynamic localization for MHCK-A, -B, and -C during polarized migration and cytokinesis.
Another feature reported earlier for MHCK-A activation is that myosin II itself stimulates autophosphorylation [ 25 ] . To test whether MHCK-C autophosphorylation is accelerated in the presence of myosin II, the stoichiometry of FLAG-MHCK-C autophosphorylation was evaluated in the presence and absence of myosin II filaments.
This result suggests that MHCK-C may be regulated in vivo by mechanisms distinct from those that regulate the activity of MHCK-A.