Words similar to mhck-a
Example sentences for: mhck-a
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As reported previously for expression of MHCK-A [ 24 ] , this selection process resulted in cell lines with increased expression level of FLAG-MHCK-C, several-fold higher than the initial expression level.
This model is consistent with the recent report that MHCK-A displays enrichment into anterior F-actin-rich protrusions of polarized cells during chemotaxis, and into phagocytic and macropinocytotic extensions [ 23 ] . The polar localization of MHCK-A would be consistent with the long-standing "polar relaxation" model for cytoskeletal reorganization during cytokinesis [ 33 ] . MHCK-A may represent a factor that contributes to polar relaxation in this system via polar disassembly of myosin II filaments.
In contrast to MHCK-A and MHCK-B distribution, GFP-MHCK-C was frequently enriched in the posterior cortex of the moving cells (Fig.
However, the strong similarity of MHCK-C to MHCK-A and MHCK-B in the conserved catalytic domain and the carboxyl-terminal WD repeat domain suggested that it might represent a third myosin heavy chain kinase in this organism.
During cytokinesis, MHCK-A displays weak enrichment at the cell poles, while MHCK-B displays a mostly diffuse localization.