Words similar to mhck-a

Example sentences for: mhck-a

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MHCK-C differs from MHCK-A and MHCK-B in that it lacks any significant amino-terminal domain upstream of the catalytic domain; conserved catalytic domain residues are present within approximately 30 residues of the methionine start codon of MHCK-C (Figure 1).
This model is consistent with the recent report that MHCK-A displays enrichment into anterior F-actin-rich protrusions of polarized cells during chemotaxis, and into phagocytic and macropinocytotic extensions [ 23 ] . The polar localization of MHCK-A would be consistent with the long-standing "polar relaxation" model for cytoskeletal reorganization during cytokinesis [ 33 ] . MHCK-A may represent a factor that contributes to polar relaxation in this system via polar disassembly of myosin II filaments.
Using epi-fluorescence microscopy, we observe strikingly different patterns of dynamic localization for MHCK-A, -B, and -C during polarized migration and cytokinesis.
These attributes are reminiscent of the behavior of MHCK-A, which upon purification exists in an unphosphorylated low activity state.
As reported previously for expression of MHCK-A [ 24 ] , this selection process resulted in cell lines with increased expression level of FLAG-MHCK-C, several-fold higher than the initial expression level.