Words similar to mga
Example sentences for: mga
How can you use “mga” in a sentence? Here are some example sentences to help you improve your vocabulary:
The genetic event(s) associated with the selection of a virulent variant of the sagA/pel mutant without changing the site or orientation of the Tn 917 transposon was reminiscent of earlier studies from our laboratory testing the virulence of mga mutants of isolate 64/14 [ 9 ] . In that study, injection of an mga mutant, that failed to express any detectable surface M or M-related protein, lead to selection of mga variants over-expressing M and M-related proteins that could be recovered from the spleen following a lethal skin infection.
For example, Mga, a transcriptional activator of M and M-related proteins, also has two transcription start sites that are independently regulated [ 11 ] and two distinct transcription start sites are associated with expression of the streptokinase gene [ 12 13 14 15 ] .
This result was reminiscent of an earlier study conducted by our laboratory using the mga mutant of isolate 64/14 [ 9 ] . In this case, although the mga mutant failed to express M or M-related proteins, however, it was capable of causing a lethal infection [ 9 ] . Detailed analysis of this system indicated that the mouse was capable of selecting an M protein over-expressing variant despite the presence of the mga mutation in an identical location [ 9 ] .
Analysis of the selected phenotypes recovered following mouse passage cannot be explained by the activities of any known regulator or combination of regulators e.g. mga [ 9 17 18 19 20 21 22 23 24 ] , nra [ 25 ] , CsrRS/CovRS [ 26 27 28 29 ] , sagA/pel [ 4 ] rofA [ 30 31 32 ] , rgg [ 33 34 35 ] , fas X [ 36 ] or luxS [ 37 38 ] .
This reversion of the M and M-related protein phenotype occurred without any change in the position or orientation of the spectinomycin-resistance cassette inserted into the mga gene to create the original mutant [ 9 ] .
Loading...