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Example sentences for: mg-

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MG-132 is a peptide aldehyde that inhibits ubiquitin-mediated proteolysis by binding to and inactivating 20S and 26S proteasomes [ 49 62 ] . Although 1-10 μM MG-132 inhibited first polar body extrusion in rat oocytes, its activity is reversible [ 42 ] . We conducted preliminary experiments to obtain a MG-132 dose range that would transiently perturb or inhibit OM during meiosis I while enabling oocytes to complete OM following washing out of the compound.
Similar results were obtained using another proteasome inhibitor, MG-132.
Proteasomes translocated to meiotic spindles of rat oocytes and MG-132 induced-inhibition of proteasomal activity resulted in partial segregation of chromosomes during meiosis I [ 42 ] . Moreover, defective proteasomal activity in fission yeast impaired chromosome segregation [ 38 ] .
Oocyte collection, culture and exposure to MG-132
The findings of the present study indicate that transient in vitro exposure of mouse oocytes to MG-132 is associated with abnormal chromosome segregation.