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Example sentences for: mg-

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The findings of the present study indicate that transient in vitro exposure of mouse oocytes to MG-132 is associated with abnormal chromosome segregation.
1D,1E) suggest that the MG-132-induced transient inhibition of proteasomal and calpain activities during meiosis I predisposed oocytes to abnormal chromosome segregation.
1A), the data indicated that MG-132 induced a dose-response perturbation or delay in the rate of OM and an increase of single, unpaired chromatids and hyperploidy in MII oocytes (Table I).
Besides inhibiting proteasome activity, the peptide aldehyde proteasome inhibitors have been also reported to repress certain lysosomal cysteine proteases and calpains [ 49 ] . The finding that MG-132 can obstruct the casein degrading activity of the calcium-dependent protease calpain [ 50 ] appears relevant to oocyte maturation.
Although the frequency of homologue separation increased with MG-132 dose, the sample size of 11 oocytes is much too low to comment about their possible origin or their influence on other abnormalities detected in MII oocytes.