Words similar to mgmt
Example sentences for: mgmt
How can you use “mgmt” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although the patterns are similar, primary tumors had a higher frequency of methylation of CDH1 and DAPK genes as compared to cell lines, while RARB , HIC1 , RASSF1A , MGMT , and TP73 genes had higher prevalence in cell lines as compared to primary tumors (Table 1).
These data, therefore, rule out the possibility that not all tumors arising from embryonic-type cells show down-regulated expression of MGMT .
However, methylation of 3 genes did suggest a doubling ( RASSF1A and MGMT ) or tripling ( BRCA1 ) of risk compared to those who did not have these genes methylated.
Our current observation that undetectable levels of MGMT gene expression in >95% of GCTs appears to suggest that the lack of the O(6)-methylguanine-DNA methyltransferase enzyme may direct cells to undergo apoptosis due to failure of repair of DNA adducts formed by alkylating agents.
In this group, all the patients that showed methylation of MGMT and BRCA1 genes failed to respond to the treatment suggesting promoter methylation of these genes may be a bad prognostic indicator (Table 2).