Words similar to mgmt

Example sentences for: mgmt

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Thus, the frequent hypermethylation in the MGMT, BRCA1 , and RASSF1A , and HIC1 define the methylation profile in NSGCT.
The overall higher frequency of promoter methylation seen in NSGCTs is noticeably evident in DNA repair genes RASSF1A, BRCA1 , and MGMT , and the hypermethylated in cancer 1 ( HIC1 ) gene, which encodes a transcription factor.
However, methylation of 3 genes did suggest a doubling ( RASSF1A and MGMT ) or tripling ( BRCA1 ) of risk compared to those who did not have these genes methylated.
Epigenetic gene silencing of the MGMT confers enhanced sensitivity to alkylating agents in cancer [ 24 25 ] . Lack of methylation, on the other hand, associates with high-risk of death [ 25 26 ] . It has been suggested that the high-levels of MGMT proteins contribute to a drug-resistant phenotype [ 27 ] . More than 90% of newly diagnosed GCTs and 70-80% of patients who present metastatic disease are cured with cisplatin-based chemotherapy [ 28 ] . However, 20-30% of the patients with metastatic disease exhibit resistance to the cisplatin curative regimen leading to high mortality in this group.
Although statistically not significant, all the patients whose tumors showed promoter methylation of MGMT (4 tumors) and BRCA1 (5 tumors) genes DOC within 1-21 months of follow-up after the initial diagnosis.