Words similar to mgmt

Example sentences for: mgmt

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Although statistically not significant, all the patients whose tumors showed promoter methylation of MGMT (4 tumors) and BRCA1 (5 tumors) genes DOC within 1-21 months of follow-up after the initial diagnosis.
To examine the biological role of promoter methylation in CC, we assessed the levels of mRNA by semi-quantitative RT-PCR in eight cell lines and compared with the respective control values obtained from the averages calculated from 2 normal cervix after normalization against ACTB . This analysis was performed on 7 genes ( CDH1 , DAPK , RARB , HIC1 , MGMT , RASSF1A , and MLH1 ) that exhibited methylation in one or more cell lines and primary tumors (Fig.
However, methylation of 3 genes did suggest a doubling ( RASSF1A and MGMT ) or tripling ( BRCA1 ) of risk compared to those who did not have these genes methylated.
One cell line (T-218A) showed no promoter hypermethylation of MGMT by MSP and no detectable levels of mRNA expression by RT-PCR but expression was reactivated after 5-Aza-2' deoxycytidine treatment.
These data, thus, showed loss of MGMT expression in majority of GCTs of all histologic subsets.