Example sentences for: mediators

How can you use “mediators” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A notable finding from our study is that exposure of NHBEs to CSC elicits the synthesis and release of a pattern of mediators similar to that seen in A549 cells in response to CSC.

  • Interestingly Ang-2 acts as an agonist for Tie2 receptors expressed on fibroblasts [ 6 ] . Since the neovascularization process is dependent on the dominance of angiogenic mediators over inhibitors, the higher Ang-1 mRNA and protein expression compared to Ang-2 in RA synovial tissue is of importance.

  • These signaling pathways in turn, activate a variety of transcription factors including NF-kappaB (p50/p65), AP-1 (c-Fos/c-Jun), and CREB phosphorylation, which in turn coordinate the induction of many genes encoding inflammatory mediators.

  • In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.

  • President Clinton halted a strike by American Airlines pilots . Using the rarely invoked Railway Labor Act of 1926, he forced the pilots to postpone the strike for two months while federal mediators try to resolve the dispute.


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