Words similar to mediators
Example sentences for: mediators
How can you use “mediators” in a sentence? Here are some example sentences to help you improve your vocabulary:
Using LPS, which we have previously shown is a rapid and potent in vitro activator of neonatal microglia [ 7 ] as our positive control, we focused our investigation on three microglia mediators which are released upon LPS activation, namely TNF-α, MMP-9 and O 2 - [ 7 ] . Our present study demonstrates that in contrast to LPS, during a 6 hour in vitro exposure to domoic acid, neonatal rat microglia release small, but statistically significant amounts of TNF-α and MMP-9.
To determine if absence of the cell death mediators FAS and FASL alter iridocorneal angle development and morphology, we assessed five mice (approximately P70) of each of the mutant strains B6.MRL- Fas lpr and B6Smn.C3H- Fasl gld , which respectively lack functional FAS and FASL [ 55, 56, 57, 58].
However, it is likely that carbohydrate and protein may differentially alter nutrient-sensing pathways such as Sir2 and mammalian target of rapomyocin (mTOR), which are gaining acceptance as mediators of the life-span extension effects of CR [16].
IL-10 is a potent monocyte/macrophage regulatory cytokine that inhibits expression of proinflammatory mediators [ 1 2 ] . Monocytes/macrophages, B cells, murine Th2 cells, and some CD8 +cells produce IL-10 [ 3 4 ] . Macrophages rapidly produce proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), IL-1 and IL-12 after activation with lipopolysaccharide or IFN-γ, while production of IL-10 is delayed.
Our present results provide the first experimental evidence to support the hypothesis that a direct interaction of domoic acid with rat neonatal microglia in vitro, leads to the release of small but statistically significant amounts of two potentially neurotoxic mediators, namely TNF-α and MMP-9 after a short-term in vitro exposure.
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