Words similar to mediators
Example sentences for: mediators
How can you use “mediators” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tumour necrosis factor-α blockade reduces synovial expression of CCL2 and CXCL8 and reduces inflammatory cell migration into RA joints [ 9 ] . In addition, these chemokines, produced by RA synovial stromal cells, have been shown to stimulate monocyte migration [ 10 ] . The functional importance of chemokines in joint inflammation has also been established in animal models of RA where antibodies to these mediators significantly reduce both the number of leukocytes recruited and the severity of disease.
Additional IL-2-responsive genes include those encoding 6 cell surface proteins, 11 cytokine and chemokine receptors, as well as 15 signal transduction mediators, 6 genes involved in cellular metabolism and biosynthesis, 3 cell cycle regulators and 12 transcription factors.
As Gorney notes, the well-meaning organization known as Common Ground Network for Life and Choice, a national project that brings pro-choice and pro-life activists together in discussion circles and makes mediators available to help resolve their differences, has succeeded mainly in inflaming partisans on both sides while producing "extremely modest tangible results."
This is an ADAM10-homolog known to be a tumor necrosis factor-α (TNFα) convertase [ 21 ] , TNFα produced by Kupffer cells in the liver stimulates production of TNFα, a mitogen for hepatocytes helping to generate new cells needed to rebuild damaged areas of the liver [ 22 ] . Kupffer cells have a significant role as mediators of acute inflammation after CCl 4 treatment; however, they also produce factors that can cause secondary injury in the liver through fibrogenic responses.
Cytosolic PLA 2 specifically hydrolyzes sn-2 arachidonate from phospholipid providing the precursors for many different lipid mediators including prostaglandins and leukotrienes [ 1 2 ] . These lipid metabolites play a role in acute inflammatory responses and also regulate normal physiological processes.
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