Words similar to mediates
Example sentences for: mediates
How can you use “mediates” in a sentence? Here are some example sentences to help you improve your vocabulary:
It remains to be determined whether FFA interacts with CD36 to activate CD36 receptor signaling, or whether CD36 mediates FFA uptake to activate src kinase and p38 MAPK signaling.
IP 3 has been shown to be an important second messenger in both bitter and sweet taste transduction, and IP 3 R3 likely mediates the Ca 2+release from intracellular stores in response to IP 3 . In bitter taste transduction, many signaling components have been identified, and IP 3 R3 is co-expressed in the same taste cells (Fig.
[ 30] indicate that TPC1 is a two-pore channel that mediates Ca 2+influx.
Studies in budding yeast identified SCF Cdc4p, an E3 ubiquitin ligase complex that mediates the ubiquitylation of the CDK inhibitor Sic1p [ 3 4 ] . SCF Cdc4pconsists of at least four proteins: the cullin Cdc53p, the RING domain protein Hrt1p/Rbx1p/Roc1p, the adapter protein Skp1p, and Cdc4p (reviewed in [ 1 ] ). Cdc4p contains two sequence motifs, which are conserved in a wide variety of so-called F-box proteins: C-terminal WD-repeats that are involved in binding the substrate Sic1p in a phosphorylation-dependent manner, and a central F-box [ 5 ] that interacts with Skp1p [ 6 7 ] . Cdc53p in turn binds to Skp1p and Hrt1p/Rbx1p/Roc1p, which bridges Cdc53p with the ubiquitin-conjugating enzyme Cdc34p/Ubc3p [ 6 8 9 10 11 12 ] . In vitro reconstitution demonstrated that SCF Cdc4p, Cdc34p, E1, ubiquitin, and ATP are sufficient to mediate Sic1p polyubiquitylation [ 6 7 ] .
To exploit the pharmacokinetics of steroids while eluding the potential complications of the use of a mammalian hormone as the inducer, the Evans laboratory developed an inducible system based on the insect steroid ecdysone and the nuclear receptor that mediates its effects.
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