Words similar to mediates

Example sentences for: mediates

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Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
Increased CD36 expression mediates sequential activation of src kinase, proapoptotic p38 MAPK, and caspase 3 in PTECs in the presence of AGE and FFA PA, resulting in PTEC apoptosis.
These results suggest that a tightly membrane-associated regulatory subunit of the α-secretase complex is likely to be the key phosphoprotein that mediates α-secretase activity as a function of its state of phosphorylation by PKC and perhaps also ERK and ROCK1.
For example, the leucine-rich domain in CCR4, mediates interaction with other proteins of the basal transcription apparatus [ 43].
This observation is consistent with the hypothesis that LPS mediates induction of TTP through the production of TNF.