Words similar to mediates

Example sentences for: mediates

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Increased CD36 expression mediates sequential activation of src kinase, proapoptotic p38 MAPK, and caspase 3 in PTECs in the presence of AGE and FFA PA, resulting in PTEC apoptosis.
TNF overproduction mediates both sepsis and chronic inflammatory disorders such as RA.
The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .
As this region of the protein is likely to contain a conserved globular domain that mediates other functional interactions of these proteins, we sought to investigate its complete diversity and potential evolutionary connections.
The crystal structure shows that the PRC-barrel domain mediates a contact with the amino-terminal cytoplasmic peptide of the PRC-M subunit and also makes contacts with the other structurally less ordered regions of the PRC-H polypeptide [ 14, 15] (Figure 1).