Example sentences for: mediates

How can you use “mediates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TRAIL clearly mediates cell death in other tissues, but also has the potential to mediate a variety of other physiological responses in bone.

  • Purification of the mammalian COP1 complex may hold a key to understand how COP1 mediates protein ubiquitination and degradation in the cells.

  • This system employs a cascade of enzymatic reactions that covalently attach a ubiquitin chain to substrate proteins, thereby targeting them to the proteasome [ 19 ] . The ubiquitin transfer reaction involves three enzymes: E1, which mediates the ATP-dependent activation of ubiquitin, and E2, or ubiquitin conjugating enzyme (UBC), which, together with an E3 ubiquitin ligase, transfers ubiquitin to the target protein.

  • Overexpressed WOX1 alone mediates apoptosis independently of p53 [ 10 ] . However, p53 apoptosis requires the participation of WOX1.

  • Previously, SPARC has been shown to regulate cell-cell contact through tyrosine phosphorylation of adherens junction proteins [ 32 ] . Electron microscopy of the SPARC-null dermal fibroblasts at wound sites should not only confirm the role of SPARC in cell motility but also reveal how SPARC mediates cell-ECM and cell-cell interactions to promote cell motility.


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