Words similar to mediates
Example sentences for: mediates
How can you use “mediates” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although Cdc5 activity (1) is necessary to free nucleolar Cdc14 in late mitosis, (2) can elicit ectopic release of Cdc14 in pre-anaphase cells when overproduced, (3) regulates the phosphorylation state of Net1 during anaphase, and (4) can disassemble native and recombinant RENT complexes in vitro by phosphorylating Net1, a combination of in vivo and in vitro phosphosite mapping and mutagenesis experiments suggest that Cdc5 mediates exit from mitosis primarily by phosphorylating targets other than Net1.
In addition, the SH3 domain of Cas mediates an interaction with FAK, C3G, CMS, and the zinc finger containing protein CIZ, while nephrocystin interacts with Cas via its SH3 domain and proline rich sequences in Cas [ 24 25 26 27 28 29 30 ] . The SH3 domain of Cas can also interact with the tyrosine phosphatase PTP1B, and expression of PTP1B in transformed cells reverts the phenotype, in part by dephosphorylating Cas [ 31 32 ] .
Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
SKP2 contains a so-called F-box, which mediates binding to SKP1, and C-terminal leucine-rich repeats that recognize p27.
The latter approach would be useful in situations where the same receptor type that mediates the beneficial effect of the drug also mediates the untoward effect [ 3 ] . In this case interaction with another receptor type could reverse the unwanted effects associated with the activation of the first receptor.
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