Words similar to mediates
Example sentences for: mediates
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Components of the SCF system are widely conserved in eukaryotes [ 1 3 ] . In human cells, for example, SCF Skp2mediates destruction of the CDK inhibitor p27 [ 13 14 ] , while SCF β-TRCPtargets IκB [ 15 16 17 ] . All of these SCF complexes share homologues of the core components CDC53/CUL1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins.
In cultured human muscle cells, only the PI 3-kinase - p70 S6 kinase pathway, and not the MAPK pathway, mediates insulin up-regulation of p85α PI 3-kinase gene expression [ 26 ] . Similarly, in L6 myotubes, insulin induces hexokinase II gene transcription via the rapamycin-sensitive PI 3-kinase pathway, but not via the MAPK pathway [ 27 ] . The PI 3-kinase - p70 S6 kinase pathway, but not the MAPK pathway, mediates insulin induction of glucose-6-phosphate dehydrogenase gene expression in primary rat hepatocytes [ 28 ] . In H411E liver cells, insulin down-regulates cAMP-induced phosphoenolpyruvate carboxykinase gene transcription via the PI 3-kinase pathway, but not via the MAPK pathway [ 29 ] . Phosphorylated p70 S6 kinase has been shown to be present in the nucleus in insulin-treated cells [ 30 ] . Moreover, it has been shown that p70 S6 kinase phosphorylates and activates members of the cAMP response element modulator family of transcription factors [ 31 ] . These data raise the possibility that transcriptional regulation of SP-A gene expression occurs via the PI 3-kinase - p70 S6 kinase pathway.
Although Cdc5 activity (1) is necessary to free nucleolar Cdc14 in late mitosis, (2) can elicit ectopic release of Cdc14 in pre-anaphase cells when overproduced, (3) regulates the phosphorylation state of Net1 during anaphase, and (4) can disassemble native and recombinant RENT complexes in vitro by phosphorylating Net1, a combination of in vivo and in vitro phosphosite mapping and mutagenesis experiments suggest that Cdc5 mediates exit from mitosis primarily by phosphorylating targets other than Net1.
For example, sensitivity to the antibacterial lipopeptide polymyxin B is affected by the PmrA-PmrB regulon, which mediates substitution of 4-aminoarabinose on the 4´ phosphate of lipid A [ 52 53 ] . By reducing the negative charge of lipid A, this modification decreases its electrostatic interaction with cationic peptides.
Thus, the present study identifies a new CD36-dependent molecular signaling pathway that mediates tubular epithelial apoptosis, and may underlie TED and IF, hallmarks of disease progression, specifically in human diabetic nephropathy.
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