Words similar to mediator

Example sentences for: mediator

How can you use “mediator” in a sentence? Here are some example sentences to help you improve your vocabulary:

The purpose of this investigation was to determine if a short-term in vitro exposure to domoic acid might activate rat neonatal microglia and cause mediator release.
[ 41 ] with kainic acid support the recently proposed notion that TNF-α might not be neurotoxic in some situations when the release of this mediator is low, and therefore might not be a necessary requirement for neuronal death involving excitatory amino acids [ 49 ] .
Such a mediator could be AS3, a gene induced by growth inhibiting levels of androgen with kinetics that precede cell cycle arrest [ 52 ] . In addition, AS3 overexpression mimics androgen-mediated cell cycle arrest in MCF7 cells stably expressing exogenous AR, while anti-sense AS3 confers resistance to androgen-induced growth arrest [ 53 ] . The function of AS3 is still unknown, but the encoded protein has features of a potential transcription factor [ 53 ] .
Breast cancer cells frequently metastasize to bone causing bone destruction and hypercalcemia [ 9 ] . Parathyroid hormone-related protein (PTHrP), secreted by these cells, is a major mediator of the osteolytic process [ 10 ] . Osteolysis leads to the release of TGFβ which, in turn, further induces PTHrP expression [ 11 ] . Other tumor-relevant genes, such as pai-1 or upa , can also be activated by TGFβ.
This hypothesis is appealing because it converges on IFN-γ as a central mediator of immune regulation within the tumor microenvironment.