Example sentences for: mediator

How can you use “mediator” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The NYT centers its coverage on the present status of the suit and whether a mediator can help bring about a settlement.

  • To further investigate the effect of SAHA on inhibition of DNA synthesis, we examined E2F-1 as a key mediator for G1 → S transition and DNA synthesis.

  • Hence resistin is a potential mediator of insulin resistance in humans with acute inflammation.

  • We have recently shown that a stimulation of microglia with LPS will lead to both TNF-α generation and MMP-9 production, a mediator that has been reported to be toxic to neuronal tissue [ 7 ] . As shown in Fig.

  • Triterpenoids are a novel family of steroid-like compounds with weak anti-inflammatory properties [ 18 ] . Synthetic triterpenoids have been produced with the aim of achieving increased potency [ 19 20 ] . 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) is a synthetic triterpenoid that has been shown to inhibit expression of the inflammatory genes inducible nitric oxide synthase and cyclo-oxygenase-2 [ 20 21 22 ] . In a recent report, MMP-1 and MMP-13 expression were induced with IL-1, a known pro-inflammatory mediator in vivo in joint tissues [ 23 ] . It was shown that CDDO could inhibit the IL-1-induced expression of these pro-inflammatory MMPs.


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