Words similar to mediator
Example sentences for: mediator
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An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
Members of the MAP kinase signaling cascade have been shown to delay apoptosis in a number of cell types [ 37 38 39 ] . Proteins belonging to this family are also involved in cell signaling leading to functional responsiveness of inflammatory cells including chemotaxis and mediator production [ 40 ] . Treatment of rats with endotoxin induced expression of total p38 and p44/42 MAP kinase in adherent vascular lung neutrophils within 0.5 hours, a response which persisted for 48 hours.
Regardless of the outcome of such experiments, our data firmly suggest that SKP2 is a central mediator of the androgen response mechanism of LNCaP cells.
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
To further investigate the effect of SAHA on inhibition of DNA synthesis, we examined E2F-1 as a key mediator for G1 → S transition and DNA synthesis.
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