Example sentences for: mediator

How can you use “mediator” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Members of the MAP kinase signaling cascade have been shown to delay apoptosis in a number of cell types [ 37 38 39 ] . Proteins belonging to this family are also involved in cell signaling leading to functional responsiveness of inflammatory cells including chemotaxis and mediator production [ 40 ] . Treatment of rats with endotoxin induced expression of total p38 and p44/42 MAP kinase in adherent vascular lung neutrophils within 0.5 hours, a response which persisted for 48 hours.

  • This hypothesis is appealing because it converges on IFN-γ as a central mediator of immune regulation within the tumor microenvironment.

  • Many studies have shown that chronic intravenous infusion of norepinephrine is sufficient to cause hypertrophy, and that various forms of hypertrophy are linked to a decrease in either beta-adrenergic receptor density or a decreased responsiveness to beta-adrenergic stimulation [ 46 48 49 56 57 58 59 60 61 62 63 ] . Barth, for example, showed that norepinephrine infusion induced left ventricular hypertrophy that could be prevented by an adrenergic-receptor blocker [ 58 ] . It has been suggested that ornithine decarboxylase is a link between beta-adrenoreceptors and stimulation of tissue growth factor, which results in hypertrophy [ 64 ] . However, recent studies have focused on alpha-adrenergic reception as a mediator of cardiac hypertrophy [ 35 ] , although some question the role of the alpha-adrenergic receptor as a hypertrophic mediator in vivo [ 34 ] . To date, no published studies of which we are aware have examined alpha-adrenergic reception and the development of cardiac hypertrophy with iron deficiency.

  • These genes have abstracts with a frequent occurrence of terms such as 'TNF' (the inflammatory mediator tumor necrosis factor), 'death' or 'apoptosis'.

  • The WP off-leads and the NYT fronts federal judge Thomas Penfield Jackson's appointment of Judge Richard Posner to act as non-binding mediator in the Justice Department's suit against Microsoft.


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