Words similar to mediated
Example sentences for: mediated
How can you use “mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:
TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
Indeed, we have found that mutation of the proline-rich region did not abolish Rlk co-precipitation with either Fyn or Lck (data not shown), suggesting that interactions between these kinases may not occur solely through an SH3 mediated interaction, at least in the 293T expression system.
Although CIA is considered a Th1-type disease mediated by IFN-γ, the role of IFN-γ in the pathogenesis of CIA is not clearly understood.
Apart from this their role in blocking the siderophore mediated iron uptake system was also studied.
Interestingly it has been demonstrated that rapid production of ROS in endothelial cells exposed to TNFα is mediated by ceramide [ 32 ] . Ceramide is a central figure in the sphingomyelin pathway, which has also been linked to stress related signaling and apoptosis [ 33 34 ] . This report provides evidence that cytokines regulate the fate of CLENDO cells.
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