Words similar to mediated
Example sentences for: mediated
How can you use “mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Other studies, however, suggested that a decrease in cAMP, rather than an increase in IP 3 , mediated bitter transduction.
The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.
However these compounds were unable to reverse the neuroprotective effects of estrogen on mitochondrial potential, suggesting that the mitochondrial effects of estrogen are non-receptor mediated.
Surprisingly, this resistance is not mediated by inhibition of the JAK-STAT1 pathway, as STAT1 phosphorylation, nuclear translocation, and DNA-binding capabilities are all preserved in the late pre-osteoclast.
Our finding that AGE-BSA and PA induce apoptosis through a CD36-mediated and p38- and caspase-dependent mechanism in tubular epithelial cells, similar to TSP-1 and ox-LDL in endothelial cells and macrophages, respectively, suggests that multiple, context-dependent extracellular stimuli of apoptosis may converge on CD36 scavenger receptor to activate src kinase and proapoptotic p38 MAPK pathway.
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