Words similar to mediate
Example sentences for: mediate
How can you use “mediate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The F-box-containing proteins of the SCF complex constitute a family of E3 ligases, key components of the ubiquitin-proteasome pathway [ 67 ] , as are many RING finger proteins [ 68 ] . The RING finger motif is thought to mediate protein-protein interactions and E3 ligase complex assembly.
Thus, Rec12 protein has one or more functions in MI that are distinct from its functions to catalyze recombination and mediate chiasmatic segregation.
12-cRSS in 3' → 5' orientation and embedded near the 3' end of V gene segments can mediate receptor editing, the replacement of the V gene segment portion of a rearranged variable-region gene with an upstream V gene segment (reviewed in [ 58]).
In humans, antigen-specific anaphylactic reactivity is thought to be mediated solely (or primarily) by IgE antibodies, whereas it has long been known that either IgE or IgG1 antibodies can mediate anaphylaxis in mice (reviewed in [ 14 15 ] and [ 17 ] ). However, it has been reported that IgG1-dependent anaphylaxis in the mouse is associated with substantially less histological evidence of mast cell degranulation than is observed in IgE-dependent anaphylaxis in that species [ 17 ] . In neither of the models of "autoimmunity" that we have studied (i.e.
While it may surprise that SKP2 overexpression alone is sufficient to mediate p27 degradation in LNCaP cells, given the known requirement for p27 phosphorylation [ 24 ] , similar observations were made in rat fibroblasts, human U87 cells, and primary rat hepatocytes [ 29 30 31 32 ] . In rat fibroblasts, these findings correlate with SKP2-induced upregulation of cyclin A and CDK2 kinase activity [ 29 32 ] , which could further augment p27 phosphorylation and degradation, ultimately stimulating cells to enter S phase.
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