Example sentences for: mediate

How can you use “mediate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recent studies have shown that elements within the 5' untranslated region (5'- UTR ) of the p27 Kip1mRNA are able to enhance translational efficiency [ 30 31 ] and several proteins that bind to the 5'- UTR have been identified [ 31 ] . The mouse p27 Kip15'- UTR has recently been shown to be able to mediate cap-independent initiation of translation [ 30 ] . In addition, a U-rich element within the p27 Kip15'- UTR may be involved in regulating p27 Kip1mRNA stability [ 32 ] . Together, these findings clearly demonstrate the importance of the 5'- UTR in controlling cellular p27 Kip1levels.

  • (This assumes, among other things, that these people have been reared in close enough proximity to these relatives to develop the emotional bonds that mediate kin-selected altruism.)

  • Genes of the ERBB family encode receptor tyrosine kinases that mediate cellular responses to growth signals.

  • The most well defined role for TECs in directly affecting thymocyte differentiation is to mediate positive selection via expression of MHC molecules [ 11 19 20 21 22 ] . However, it is still unclear whether TECs directly promote specific stages of thymocyte differentiation during stages that do not involve MHC-TCR interactions, or whether their role at other stages is primarily to promote cell growth and /or survival.

  • Indeed, obesity is associated with elevated levels of cytokines whose systemic administration leads to impaired glucose homeostasis [36,44,45], such as TNFα and IL-6, which we show here to mediate the inflammatory induction of human resistin.


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