Example sentences for: mediate

How can you use “mediate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These include effects on other translational control proteins including p70 S6 kinase (p70S6K), eIF4G, eIF4B, and eEF2 (reviewed in [ 23 ] ). At present neither the targets that are essential for inhibition of cell proliferation by rapamycin nor the mechanism by which these targets mediate cell cycle arrest are completely understood.

  • The η-η' interaction has been primarily observed to mediate a conformational change between the two steps of splicing [ 17 ] . It is also missing from some mitochondrial class A1 and bacterial classes B, C and D intron structural groups, which may indicate that it is not absolutely essential for splicing.

  • VEGF has also been shown to mediate the vessel growth that characterizes tumor expansion as well as the neovascularization that is associated with diabetic retinopathy.

  • 5Band 5C), the former possibly mediated by glucocorticoid-induced insulin resistance and the latter possibly mediated by the resulting hyperinsulinemia, might mediate the observed effect of corticosterone implants on hypothalamic POMC in these implanted mice.

  • Well studied examples of these are the bromodomain that interacts with acetylated peptides [ 14, 15, 16], chromodomains that mediate specific interactions with proteins [ 17, 18] and RNA [ 19, 20], the PHD finger mediating protein-protein interactions [ 21], the Myb and SANT domains [ 22] that interact with both DNA and proteins [ 23], and the SAP and AT-hook domains that interact with DNA [ 24, 25].


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