Words similar to mediate
Example sentences for: mediate
How can you use “mediate” in a sentence? Here are some example sentences to help you improve your vocabulary:
About two decades ago, it became widely appreciated that many of the cell surface receptors that mediate cell–cell and cell–ECM interactions were structurally and functionally related, and the term “integrins” was coined to reflect the capacity of members of this family to integrate the extracellular and intracellular environment (Hynes 1987).
p27 specifically inhibits CDKs, which mediate entry into S phase [ 10 11 ] . The level of p27 is higher in quiescent than in proliferating cells, and this increase in p27 abundance is required for an effective cell cycle exit [ 12 ] . The cell cycle-dependent variations in p27 levels are not reflected by similar changes in p27 mRNA [ 13 ] . Many aggressive prostate cancers display decreased p27 protein levels in the presence of high p27 mRNA [ 14 ] , suggesting that p27 depletion may result from ectopic proteolysis.
Although MHCII are not expressed by the vast majority of studied mouse and human tumors, CD4+ T lymphocytes specific to MHCII-restricted tumor antigens have been found in various cancers [ 1 ] . Those lymphocytes are believed to be generated in vivo following the recognition of MHCII-tumor peptide complexes expressed by host antigen presenting cells and can cause regression of MHCII-negative tumors indirectly, via secretion of cytokines such as IL-2 or IFNg [ 2 ] . The released cytokines can recruit and activate cytotoxic CD8+ T lymphocytes and/or accessory cells (eosinophills, macrophages) which further mediate tumor destruction.
It has been hypothesized that statins mediate their effects by increasing the expression in bone of the growth factor bone morphogenic protein-2 (BMP-2) which in turn leads to osteoblast differentiation and bone formation [ 2 ] . This mechanism of action has been addressed by Baumann et al.
However, fasting can influence hypothalamic gene expression in insulin-deficient mice independent of changes in plasma leptin or insulin [ 5 ] , as well as in leptin resistant db/db mice [ 3 ] . These data suggest that other factors in addition to leptin may mediate effects of fasting.
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