Words similar to inhibitors
Example sentences for: inhibitors
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Examples of new kinase inhibitors include gefitinib and erlotinib, which have recently shown promise in treating non-small-cell lung cancer.
In the past, these compounds have been widely used as specific p38 inhibitors [ 12 ] and their inhibitory action has been well documented [ 13 14 15 ] . However, recent results show that, in a comparable concentration range they inhibit the serine/threonine kinase activity of TGFβ type I receptor preventing phosphorylation of R-Smads [ 16 17 18 ] .
We have identified 4-(N, N-dipropylamino)benzaldehyde (DPAB) (Figure 1B) and 4-(N, N-diethylamino) benzaldehyde (DEAB) as potent, selective inhibitors of ALDH1A1, but not ALDH2 or ALDH3, with the dipropyl analog exhibiting 10-fold greater efficacy for inhibition [ 19 20 ] . The effect of DPAB on ALDH1A2 has not been reported.
HDAC inhibitors, such as trichostatin A and trapoxin, modulate gene expression in either a positive, negative or neutral fashion [ 45].
Beads containing GST proteins were collected by low speed centrifugation, followed by three successive washes with PBS containing 0.1% Triton X-100 and the protease inhibitors described above.
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