Words similar to inhibiting
Example sentences for: inhibiting
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Moreover, treatment of the macrophages with SN50, a cell-permeable peptide that specifically prevents activation of NF-κB by inhibiting its nuclear translocation [34], nearly abolished endotoxin-induced activation of resistin expression (Figure 4D).
It is generally accepted that the hydroxy acid form of statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that plays a critical role in cholesterol metabolism, where they block substrate accessibility to HMG-CoA reductase, effectively subverting cholesterol levels of HDL [ 19 20 21 ] . In addition to lowering cholesterol, statins seem to have a number of additional effects, such as the nitric oxide-mediated promotion of new blood vessel growth [ 22 ] , protection against oxidative modification of low-density lipoprotein, as well as anti-inflammatory effects and a reduction in C-reactive protein levels [ 23 ] . All statins limit cholesterol biosynthesis by inhibiting the committed step in the biosynthesis of isoprenoids and sterols [ 24 ] .
The functional significance of SNIP1 degradation is apparent, since SNIP1 is a constitutive interactor and functional repressor of the master transcription co-activator CBP/p300 [ 25 ] . In the BMP signaling pathways, SNIP1 is a potent inhibitor of Smad-responsive genes via inhibiting CBP/p300 (Fig.
Point estimation techniques have the advantage of providing a point estimate of the toxicant concentration causing a given amount of adverse (inhibiting) effect, the precision of which can be quantitatively assessed (1) within tests by calculation of 95% confidence limits, and (2) across tests by calculating a standard deviation and coefficient of variation.
The auto-inhibitory domain is involved in inhibiting the enzyme activity in the absence of Ca 2+whereas the variable region at the amino terminus may account for their substrate specificity and/or localization [ 22].
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