Example sentences for: inactivation

How can you use “inactivation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This phenotype caused by inactivation of Rho is the first to be described in T lymphocytes, however, Rho regulation of the actin cytoskeleton is not novel among cells of the hematopoietic lineage.

  • In control cells, inactivation was complete when the pre-pulse potential was above +30 mV (-6.

  • First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.

  • Association of APC promoter methylation with MSI phonotype has been previously reported in endometrial cancer [ 45 ] . Although the significance of these results is currently unclear, we believe that inactivation of these genes by promoter methylation causes microsatellite instability and may contribute to the development of CC.

  • Furthermore, pre-pulse potentials larger than +30 mV did not promote additional inactivation, which can be seen by comparing traces 2 and 3 in the γ 1 het and γ 1 null cells.


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