Example sentences for: inactivation

How can you use “inactivation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Hyaluronidases Hyal-1 and Hyal-2 play a critical role in cancer invasion and metastasis [ 3 4 5 ] , although inactivation of HYAL1 gene has been shown in head and neck squamous cell carcinomas [ 17 ] . Hyal-1, also known as Luca-1, is a lysosomal enzyme that is secreted from cells.

  • However, shifts in voltage dependence below the limit of resolution (see Materials and Methods) and effects on charge movement and Ca 2+release inactivation cannot be completely ruled out.

  • The degree of skewing was calculated by subtracting 50 from the observed degree of inactivation.

  • Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.

  • In conclusion, we suggest that X-chromosome inactivation needs to be considered as a potential factor in the predominance of females in most autoimmune diseases.

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