Example sentences for: inactivating

How can you use “inactivating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The pattern of such promoter methylation has been noted to be non-random in various tumor types, while certain genes are commonly methylated in diverse tumor types [ 10 11 ] . The extent of aberrant promoter hypermethylation and its association with loss of gene function in cancer suggests that CpG island methylation is an important mechanism in inactivating tumor suppressor genes (TSGs).

  • The latter event was shown to be blocked by CAP [ 8 ] and has been considered the basis for the virus inhibitory and virus inactivating properties of CAP at neutral pH.

  • MG-132 is a peptide aldehyde that inhibits ubiquitin-mediated proteolysis by binding to and inactivating 20S and 26S proteasomes [ 49 62 ] . Although 1-10 μM MG-132 inhibited first polar body extrusion in rat oocytes, its activity is reversible [ 42 ] . We conducted preliminary experiments to obtain a MG-132 dose range that would transiently perturb or inhibit OM during meiosis I while enabling oocytes to complete OM following washing out of the compound.

  • Instead, this amino-terminal mutation favored elevated caspase 3 levels that subsequently facilitated enhanced apoptosis by inactivating the caspase-dependent DNA repair proteins PARP and by inactivating DFF45, an inhibitor of the caspase-dependent DNase, DFF40.

  • Three independent mouse lines carrying inactivating Pten mutations have been made [ 23, 24, 25].


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