Words similar to inactivating
Example sentences for: inactivating
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4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.
Three independent mouse lines carrying inactivating Pten mutations have been made [ 23, 24, 25].
MG-132 is a peptide aldehyde that inhibits ubiquitin-mediated proteolysis by binding to and inactivating 20S and 26S proteasomes [ 49 62 ] . Although 1-10 μM MG-132 inhibited first polar body extrusion in rat oocytes, its activity is reversible [ 42 ] . We conducted preliminary experiments to obtain a MG-132 dose range that would transiently perturb or inhibit OM during meiosis I while enabling oocytes to complete OM following washing out of the compound.
CAP in micronized form and formulated into a cream, is a broad spectrum microbicide inactivating several sexually transmitted disease (STD) pathogens [ 2 3 4 ] , including HIV-1 [ 2 5 ] . It was of interest to explore the mechanism(s) whereby CAP causes inactivation of HIV-1.
The abnormal aggregated species can recruit normal soluble PrP molecules into aggregates, thus inactivating them.
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