Words similar to inactivating
Example sentences for: inactivating
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Other epigenetic mechanisms involving defects in chromatin modification factors such as the association of methyl-CpG binding proteins, acetylation and methylation of histone proteins are also becoming known [ 15 ] . The role of these chromatin-mediated components in inactivating the MGMT gene remains to be examined in GCT.
As with PrP Sc , yeast prions efficiently recruit soluble molecules of the same species, thus inactivating them (Lindquist 1997; Chernoff 2001; Wickner et al.
Separase is needed for inactivating cohesions and enabling sister chromatid separation [ 35 36 37 ] in both fission yeast [ 38 ] and mammalian cells [ 39 ] . Although differences have been reported among species [ 40 ] and cell types [ 41 ] , it appears that the majority of cohesion is removed from mammalian chromosomes during prophase and prometaphase; whereas, a lesser amount remains at kinetochores until anaphase onset.
We have shown previously that antagonism of the slowly activating non-inactivating granulosa K +current (I Ks ) enhances basal progesterone production by depolarizing membrane potential and thus enhancing calcium influx via pimozide-sensitive Ca 2+channels [ 18 ] . In contrast, Kusaka [ 21 ] showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and LH-stimulated progesterone production.
Taken together, these results suggest that statins influence APP processing, at least in part, by modulating the isoprenoid pathway and inactivating the ROCK1 kinase.
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