Example sentences for: inactivates

How can you use “inactivates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.

  • However, the introduction of a mutation into one subunit of a single-chain heterodimer causes a defect in only one half-site and therefore inactivates only one of the two RNA-binding sites.

  • Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.

  • The same effects were seen when they transfected the cells with a dominant negative form of ROCK1 (which inactivates the normal ROCK1 molecules in the cell); this outcome shows that the pathway can influence APP cleavage.

  • They showed that replacement of the cytoplasmic-transmembrane regions by an artificial linkage between the tails inactivates the receptor, whereas breakage of the clasp activates the receptor (Lu et al.


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