Words similar to inactivated
Example sentences for: inactivated
How can you use “inactivated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tumour suppressor genes were genes that would normally prevent a tumour from happening and that needed to be inactivated for a tumour to start to form; both copies of a tumour suppressor gene had to be inactivated, and the mutation was recessive.
It is unknown if there is a regulator or a series of regulators that are inactivated or activated after passage through the mouse; however, it is clear that key virulence factors are under a more complex pattern of regulation than previously envisaged.
Tem1 is thought to be kept inactive throughout early mitosis by the two-component GTPase-activating protein complex Bub2/Bfa1 which co-localizes with Tem1 at the spindle pole body [ 10 11 ] . When the mitotic spindle penetrates the mother-daughter neck, the Tem1-bound spindle pole body is translocated into the daughter cell where a cortical pool of Lte1 is thought to activate Tem1 [ 12 13 ] . In addition to this spatial regulation, the GTPase activity of Bfa1 is thought to be inactivated through its phosphorylation by Cdc5 [ 14 ] , but it remains unknown how this process is coordinated with the presumed juxtaposition of Lte1 and Tem1 in the daughter cell.
GSK3β is constitutively active in resting cells, and is inactivated by PKB through the growth factor dependent p110-PI 3-kinase pathway [ 25, 28, 29].
To determine if the wild type allele of Pten was inactivated in tumors arising in a Pten +/- background, 11 tumors from Wnt-1 TG, Pten +/- mice were examined for LOH by Southern hybridization.