Words similar to inactivated
Example sentences for: inactivated
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These Ca 2+conductances were approximately 10% higher than those at the -40 mV holding potential reported in Table 1. The additional current could have been contributed by T-type Ca 2+channels (not shown), which are available at the -80 mV holding potential but are inactivated at the more positive holding potential.
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
The fact that the 41-year-old and 44-year-old human samples, as well as the murine hypothalamus samples, were both obtained from males implies that differential expression of X-inactivated polymorphic alleles cannot explain the observed differences.
sα i2 may exist in a state that does not interact well with βγ simply because it is in the process of being irreversibly inactivated [ 9 10 ] . Similarly, α i2 A327S appears not to be defective in its intrinsic ability to interact βγ [ 10 ] , and co-expression of βγ shifts α i2 A327S, like sα i2 , from intracellular to plasma membranes (Figure 8).
Enzymes were inactivated by heat treatment at 85°C for 15 min.
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