Words similar to inactivated
Example sentences for: inactivated
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Furthermore, we found that a region of the X chromosome at which many X-inactivated genes are located is quite L1-poor, a finding that is contrary to a direct role for L1s in X inactivation.
Positive counts in the BJAB-B1 cells exposed to inactivated CMV represents non-specific staining.
(Fuangthong and Helmann 2002) can be inactivated by H 2 O 2 or by organic peroxides (ROOH) formed by the oxidation of a variety of organic molecules in the cell or in the environment.
The human FHIT gene, located at the chromosome 3 fragile site FRA3B, is inactivated early in the development of many tumors [ 1 ] . Murine Fhit is also located at a fragile site [ 2 3 ] and mice heterozygous for disruption of Fhit , given low intragastric doses of the mutagen N-nitrosomethylbenzylamine, develop stomach and sebaceous tumors [ 4 ] that can be prevented by viral Fhit expression [ 5 ] . Fhit, a dimer of 147 amino acid subunits, is a member of the histidine triad (HIT) superfamily of nucleotide hydrolases and transferases [ 6 7 ] . Members of the Hint branch of the HIT superfamily are found in all forms of life [ 8 ] . The S. cerevisiae Hint homolog, Hnt1, and rabbit Hint possess adenosine monophosphoramidase activity that functions in yeast to positively regulate function of Kin28, Ccl1 and Tfb3, which constitute the kinase component of general transcription factor TFIIH [ 9 ] . A new Hint related protein, Aprataxin, is mutated in individuals with ataxia with oculomotor apraxia [ 10 11 ] and has a yeast homolog termed Hnt3 [ 9 ] . Members of the Fhit branch of the HIT superfamily have been found in fungi [ 12 13 ] , animals [ 2 14 15 ] and plants [ 7 ] and hydrolyze diadenosine tetraphosphate, diadenosine triphosphate and other 5'-5"'-dinucleoside polyphosphates.
In an effort to identify the genes inactivated in the recurrent 5p deletions in CC, we identified candidate genes with tumor suppressor function.
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