Example sentences for: hydroxyl

How can you use “hydroxyl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The metal cations direct a 5' nucleoside triphosphate to form a phosphoester bond with the 3' hydroxyl of the preceding nucleotide (the 3'-terminal nucleotide of a growing polynucleotide chain), with the elimination of pyrophosphate [ 6 ] .

  • A variation on this theme is that it might never be possible to construct a phosphosite mutant of Net1 that binds Cdc14 but fails to release it during anaphase, if the hydroxyl groups that are phosphorylated normally form critical hydrogen bonds that tether Cdc14 to Net1.

  • However, this model is difficult to envision since the DNase I and hydroxyl radical cleavage patterns extend over seven to nine turns of DNA.

  • Variations at residues alpha4 Thr183 and beta2 Ala135 generate different shapes of the binding pocket (Figure 4- Top), but preserve the electrostatic potential of the system: all non-conserved residues at position 183 are hydrophobic, and hydroxyl of Thr154 and Ser154 are superimposed, pointing away from the ligand, towards the carboxylate of Asp122.

  • Structural variation (changing X, Y, and the position of the hydroxyl group) can be used for membrane permeability adjustment, enhancement of oral bioavailability and improvement of Blood-Brain Barrier penetration.


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