Example sentences for: hydroxy-

How can you use “hydroxy-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is generally accepted that the hydroxy acid form of statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that plays a critical role in cholesterol metabolism, where they block substrate accessibility to HMG-CoA reductase, effectively subverting cholesterol levels of HDL [ 19 20 21 ] . In addition to lowering cholesterol, statins seem to have a number of additional effects, such as the nitric oxide-mediated promotion of new blood vessel growth [ 22 ] , protection against oxidative modification of low-density lipoprotein, as well as anti-inflammatory effects and a reduction in C-reactive protein levels [ 23 ] . All statins limit cholesterol biosynthesis by inhibiting the committed step in the biosynthesis of isoprenoids and sterols [ 24 ] .

  • An example of the first scenario is o -succinylbenzoate synthase, which catalyzes the dehydration of 2-hydroxy-6-succinyl-2,4-cyclohexadiene carboxylate to form o -succinylbenzoate synthase in the biosynthetic pathway for menaquinone synthesis.

  • It has been shown that HIV-infected brain has a decrease of mRNA and protein of the GluR-A flop subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor in cerebellar Purkinje cells.

  • Bromodeoxyuridine (BrDU) incorporation into DNA, a measure of cell proliferation, and enzymatic end labeling of 3'-hydroxy-DNA strand breaks, a measure of apoptosis, were quantified in situ as we have reported previously [ 10 ] .

  • NMDA, N-methyl-D-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GluR, glutamate receptor; SPM, crude synaptic membrane; CaMKII, calcium/calmodulin-dependent protein kinase II; SDS PAGE, sodium dodecyl sulfate electrophoresis.


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