Words similar to hydroxy
Example sentences for: hydroxy
How can you use “hydroxy” in a sentence? Here are some example sentences to help you improve your vocabulary:
Detection of the active Simvastatin hydroxy acid metabolite in mouse serum after gavage administration
It is generally accepted that the hydroxy acid form of statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that plays a critical role in cholesterol metabolism, where they block substrate accessibility to HMG-CoA reductase, effectively subverting cholesterol levels of HDL [ 19 20 21 ] . In addition to lowering cholesterol, statins seem to have a number of additional effects, such as the nitric oxide-mediated promotion of new blood vessel growth [ 22 ] , protection against oxidative modification of low-density lipoprotein, as well as anti-inflammatory effects and a reduction in C-reactive protein levels [ 23 ] . All statins limit cholesterol biosynthesis by inhibiting the committed step in the biosynthesis of isoprenoids and sterols [ 24 ] .
The quantitation was based on integration of the area under the respective peaks in the UV spectra obtained at 240 nm (approximately the λ max for both simvastatin and simavastatin hydroxy acid).
The only two clear exceptions to this pattern of poorly conserved proteins primarily involved in defense and extracellular signaling were the mammalian enzymes hydroxysteroid sulfotransferase and hydroxy acid oxidase.
Recovery of simvastatin and of simavastatin hydroxy acid from mouse plasma following the extraction procedure below, was assessed by comparison of samples at three doses (30, 80 and 150 ng), which were used to spike 0.1 ml mouse plasma followed by extraction and injection into LC-MS, to similar doses directly injected to the LC-MS.
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