Words similar to hydroxylases
Example sentences for: hydroxylases
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This relationship, along with the combination to the intracellular MYND domain and the lack of signal peptides, suggests that the Egl-9 family proteins are prolyl hydroxylases that modify intracellular proteins, unlike the classic prolyl hydroxylases that have been implicated primarily in the modification of collagens in the endoplasmic lumen.
The amino-acid hydroxylases show the greatest diversify in eukaryotes, and are represented in a number of different forms in both animals and plants.
The conservation of all the residues implicated in catalysis in the biochemically uncharacterized proteins such as AlkB, EGL-9, leprecan and YbiX suggests they all catalyze oxidative reactions similar to those catalyzed by IPNS, DAOCS, CAS and related enzymes such as protein lysyl/prolyl hydroxylases, EFE and leucoanthocyanidin oxidases [ 1, 2].
In contrast, the predicted amino-acid hydroxylases of the EGL-9 family are seen sporadically, in single copies, in certain bacterial lineages such as V. cholerae and Ps.
The closest relatives of the EGL-9 family are the proline hydroxylases with which they share a region of specific extended conservation amino terminal to the core DSBH domain (Figure 1).
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