Words similar to hmg-boxes
Example sentences for: hmg-boxes
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The Fugu HMG-box sequences are nearly identical to mammalian TOX HMG-boxes, and the exon/intron boundary encoding the box is at the characteristic position (Fig.
Despite high similarity in overall structure between HMG-boxes, individual domains exhibit distinct DNA binding characteristics as discussed above, and can interact with DNA in different orientations.
Although there are few amino acid positions within the HMG-box motif that are conserved throughout the HMG-box protein superfamily, there are highly conserved residues within sequence-dependent and sequence-independent subgroups [ 21 ] . The vast majority of HMG-boxes have a tryptophan in helix 2, often as part of a GXXW motif (where X denotes any amino acid) [ 3 5 ] . Similarly, TOX has a tryptophan at this position, although as part of the less commonly found AXXW sequence.
For example, RAG1 has been reported to interact with the tandem HMG-boxes of HMGB1 or HMGB2 [ 6 ] . Where it has been studied, HMG-boxes have been shown to be structurally related, forming three α-helices in a characteristic L-shaped structure [ 3 7 ] . The distortion of DNA by the HMG-box is primarily mediated through contacts with the minor groove of the DNA helix, potentially allowing simultaneous binding of other transcriptional regulators to the DNA [ 8 9 ] . The HMG-box family has often been subdivided based on DNA binding properties.
There is also complete identity of the HMG-boxes between murine and human homologues of a given family member, consistent with formation of the Tox subfamily by gene duplication prior to the rodentia and primate split.
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