Words similar to hmg-boxes
Example sentences for: hmg-boxes
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There is also complete identity of the HMG-boxes between murine and human homologues of a given family member, consistent with formation of the Tox subfamily by gene duplication prior to the rodentia and primate split.
For example, RAG1 has been reported to interact with the tandem HMG-boxes of HMGB1 or HMGB2 [ 6 ] . Where it has been studied, HMG-boxes have been shown to be structurally related, forming three α-helices in a characteristic L-shaped structure [ 3 7 ] . The distortion of DNA by the HMG-box is primarily mediated through contacts with the minor groove of the DNA helix, potentially allowing simultaneous binding of other transcriptional regulators to the DNA [ 8 9 ] . The HMG-box family has often been subdivided based on DNA binding properties.
Although there are few amino acid positions within the HMG-box motif that are conserved throughout the HMG-box protein superfamily, there are highly conserved residues within sequence-dependent and sequence-independent subgroups [ 21 ] . The vast majority of HMG-boxes have a tryptophan in helix 2, often as part of a GXXW motif (where X denotes any amino acid) [ 3 5 ] . Similarly, TOX has a tryptophan at this position, although as part of the less commonly found AXXW sequence.
Despite high similarity in overall structure between HMG-boxes, individual domains exhibit distinct DNA binding characteristics as discussed above, and can interact with DNA in different orientations.
The Fugu HMG-box sequences are nearly identical to mammalian TOX HMG-boxes, and the exon/intron boundary encoding the box is at the characteristic position (Fig.
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