Example sentences for: hmgcoa

How can you use “hmgcoa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Statins block HMGCoA reductase generation of mevalonate from 3-hydroxy-methyl-glutarate (see Figure 7).

  • To test whether statin-activated shedding might be attributable to a metabolite downstream of HMGCoA reductase, cells were treated with 1 μM simvastatin, 5 μM FTI-1, and a series of concentrations of mevalonic acid.

  • Since FTI-1 acts downstream of HMGCoA reductase, the stimulatory effect of FTI-1 on sAPP α shedding would not be predicted to be modified by mevalonate supplementation.

  • Reports from retrospective analyses suggest that the statin class of cholesterol-lowering HMGCoA reductase inhibitors may lower the risk for Alzheimer disease by as much as 70% [8,9,10,11].


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