Words similar to hmg
Example sentences for: hmg
How can you use “hmg” in a sentence? Here are some example sentences to help you improve your vocabulary:
Three published [ 1 2 3 ] and one recently presented [ 4 ] randomized placebo-controlled clinical trial have unequivocally demonstrated that 3-Hydroxy-3-methylgluatryl coenzyme A (HMG CoA) reductase inhibitors (statins) reduce the morbidity and mortality associated with coronary disease.
Many of these structural changes are mediated by high mobility group (HMG) proteins, a diverse superfamily of non-histone chromosomal proteins that were originally classified by their electrophoretic mobility [ 1 ] . HMG proteins contain DNA-binding domains that allow them to produce specific changes in target DNA structure [ 2 3 ] . Three structurally distinct classes of HMG proteins have been defined; the HMG-nucleosomal binding family, the HMG-AT-hook family, and the HMG-box family (whose canonical members are referred to as HMGN, HMGA and HMGB respectively) [ 4 ] . In addition, a large number of proteins have been found that contain HMG protein related motifs.
Note that several genes for proteins involved in cholesterol biosynthesis (HMG CoA reductase, IDI1, sterol C4 methyl oxidase) and fatty acid metabolism (ACAT2, DEGS, ACATN, FACL3, PEC1) were modulated by R1881.
Database searches of genomic sequences from Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (roundworm), and Strongylocentrotus purpuratus (sea urchin) did not reveal genes encoding the TOX HMG signature sequence (data not shown).
The documentation of this unique subfamily of HMG box proteins is a necessary initial step in evaluation of their biological function.
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