Words similar to hmg
Example sentences for: hmg
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Database searches of genomic sequences from Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (roundworm), and Strongylocentrotus purpuratus (sea urchin) did not reveal genes encoding the TOX HMG signature sequence (data not shown).
Many of these structural changes are mediated by high mobility group (HMG) proteins, a diverse superfamily of non-histone chromosomal proteins that were originally classified by their electrophoretic mobility [ 1 ] . HMG proteins contain DNA-binding domains that allow them to produce specific changes in target DNA structure [ 2 3 ] . Three structurally distinct classes of HMG proteins have been defined; the HMG-nucleosomal binding family, the HMG-AT-hook family, and the HMG-box family (whose canonical members are referred to as HMGN, HMGA and HMGB respectively) [ 4 ] . In addition, a large number of proteins have been found that contain HMG protein related motifs.
Nuclear localization signals are also highly conserved in SRY-box and other HMG-box proteins [ 37 ] . Basic residues outside of the HMG box motif may also function to stabilize DNA binding by these proteins [ 38 ] .
Systematic reviews and recent trials have found that lipid-lowering therapy with HMG co-A reductase inhibitors (statins) can reduce the relative risk of future CHD events by approximately 30% and that this relative risk reduction appears to be similar for patients with different levels of CHD risk.
The documentation of this unique subfamily of HMG box proteins is a necessary initial step in evaluation of their biological function.
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