Words similar to hmg-box
Example sentences for: hmg-box
How can you use “hmg-box” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this study, we introduce a subfamily of three additional mammalian proteins, which share a common HMG-box domain with TOX.
UBF-1 specifically binds the ribosomal RNA gene promoter, although no particular recognition sequence can be identified [ 22 ] . HMGB1 and UBF-1 contain multiple HMG-box motifs, although only one is shown (indicated by decimal in Fig.
Tox is the murine homologue of the human gene KIAA0808, previously isolated from brain tissue [ 29 ] . TOX and KIAA0808 are approximately 90% identical at both the nucleotide and amino acid level [ 15 ] . Using BLAST program searches [ 30 31 ] we have now identified 3 other murine genes that are predicted to encode proteins that have nearly identical HMG-box sequences to TOX (Fig.
The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.
TOX is a member of a four-protein subfamily with nearly identical HMG-box sequences
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