Example sentences for: hmba
How can you use “hmba” in a sentence? Here are some example sentences to help you improve your vocabulary:
The larger measures approximately 500 kDa and contains the hexamethylene bisacetamide (HMBA)–induced protein 1 (HEXIM1) and 7SK small nuclear RNA (snRNA) in addition to P-TEFb [24,25].
HEXIM1 was identified as the inducible gene following the exposure of vascular smooth muscle cells to a potent differentiating agent, HMBA [26].
Although treatment with HMBA induces remission in patients with myelodysplastic syndrome and acute myelogenoud leukemia, it is not currently used therapeutically because of the high dosage required (millimolar blood levels) and the accompanying toxic side effects (thrombocytopenia) [ 21].
In this study, we report a novel mechanism of cell growth inhibition by the second generation of HPCs, named SAHA, which is 2000-fold more potent than HMBA and bears at least one hydroxamide in place of the amides in HMBA [ 17].