Words similar to haploinsufficient

Example sentences for: haploinsufficient

How can you use “haploinsufficient” in a sentence? Here are some example sentences to help you improve your vocabulary:

The nature and variability of anterior segment phenotypes of Bmp4 +/-heterozygotes resemble those we reported in mice with dominant mutations in the forkhead box genes Foxc1 and Foxc2 [ 42 ] . However, the Bmp4 haploinsufficient phenotype is typically more severe.
Since then, haploinsufficient mechanisms have been described in more tumour suppressor genes in humans and mice (reviewed in Fodde and Smits 2002).
There is a long-standing debate in the literature about the number and role of mutations in a tumour, and without going into the details, it is clear that haploinsufficient mechanisms for tumour suppressor genes will greatly influence the statistics on which these discussions are based.
It is presently unknown whether autosomal dominant lamin A/C mutations impart their phenotype through dominant negative or haploinsufficient mechanisms.