Example sentences for: haploinsufficiency

How can you use “haploinsufficiency” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Retinal dysplasia is characterized by palisading outer retinal cells that surround a central lumen [ 57 ] . It occurs in mice with a variety of genetic defects and in some instances is associated with abnormalities of the retinal pigment epithelium [ 58 59 60 61 62 ] . Both during development and in adult life, the retinal pigment epithelium is critical to retinal function [ 63 ] . BMP2 and 4 may act as negative growth regulators in the retinal pigment epithelium [ 64 ] . It is possible that haploinsufficiency of BMP4 in the retinal pigment epithelium may be responsible for focal retinal dysplasia and displacement of photoreceptor nuclei.

  • Vertebrate retinal development is an intricate process involving complex pathways that are not completely understood [ 47 48 49 50 51 52 53 ] . Although our cell marker analysis indicates that all major retinal cell types differentiate, haploinsufficiency of BMP4 results in a variety of retinal abnormalities.

  • This strongly suggested that a decrease of dosage in p53 is already sufficient for tumourigenesis, a phenomenon referred to as haploinsufficiency.

  • As shown here, haploinsufficiency of BMP4 causes a variety of ocular abnormalities that are strongly influenced by strain-specific modifier genes.

  • This suggests that MYOC haploinsufficiency is not causative for glaucoma and that myocilin may even be dispensable or redundant in normal human development or only important when ocular stress occurs.


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