Words similar to haploinsufficiency
Example sentences for: haploinsufficiency
How can you use “haploinsufficiency” in a sentence? Here are some example sentences to help you improve your vocabulary:
In fact, an investigation of Brn3c heterozygotic mice showed no additional effect on hearing loss due to haploinsufficiency in these mice [ 35 ] . Our data on Brn3c null mouse mutants nevertheless suggest that the high to low frequency progressive hearing loss in humans may correlate with the unknown factor(s) that mediate apical spiral neuron survival into adulthood.
This suggests that MYOC haploinsufficiency is not causative for glaucoma and that myocilin may even be dispensable or redundant in normal human development or only important when ocular stress occurs.
This strongly suggested that a decrease of dosage in p53 is already sufficient for tumourigenesis, a phenomenon referred to as haploinsufficiency.
As shown here, haploinsufficiency of BMP4 causes a variety of ocular abnormalities that are strongly influenced by strain-specific modifier genes.
Retinal dysplasia is characterized by palisading outer retinal cells that surround a central lumen [ 57 ] . It occurs in mice with a variety of genetic defects and in some instances is associated with abnormalities of the retinal pigment epithelium [ 58 59 60 61 62 ] . Both during development and in adult life, the retinal pigment epithelium is critical to retinal function [ 63 ] . BMP2 and 4 may act as negative growth regulators in the retinal pigment epithelium [ 64 ] . It is possible that haploinsufficiency of BMP4 in the retinal pigment epithelium may be responsible for focal retinal dysplasia and displacement of photoreceptor nuclei.
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