Example sentences for: haplotypic

How can you use “haplotypic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine if a subset of these 12 SNPs could account for most of the haplotypic diversity in these samples, we calculated entropy for all possible subsets of SNPs, increasing the number of SNPs in a subset from 1 to 12.

  • We developed an algorithim that chooses SNPs, first individually, then in multi-SNP haplotypes, that maximize entropy [ 35 ] . Thus we can define a subset of SNPs that represent the greatest proportion of the full 12-SNP haplotypic diversity.

  • To account for 95% of the haplotypic diversity of TNF , one must genotype 8 of 12 SNPs in The Gambian sample (in order of decreasing informativeness): -3025, -308, 851, -1031, -857, 467, -244, -238; and type 7 SNPs in the Malawian sample: -3025, -1031, 851, -308, 1304, -244, -1073.

  • There are a number of interesting features that distinguish these two populations at the haplotypic level.

  • In African populations, three TNF promoter SNPs have been independently associated with severe malaria [ 1 2 3 ] . To better understand these complex genetic associations with malaria, we have defined the haplotypic structure of the TNF gene region using 12 SNPs genotyped in 212 Gambian and 84 Malawian adults.


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