Words similar to haplotypic
Example sentences for: haplotypic
How can you use “haplotypic” in a sentence? Here are some example sentences to help you improve your vocabulary:
To account for 95% of the haplotypic diversity of TNF , one must genotype 8 of 12 SNPs in The Gambian sample (in order of decreasing informativeness): -3025, -308, 851, -1031, -857, 467, -244, -238; and type 7 SNPs in the Malawian sample: -3025, -1031, 851, -308, 1304, -244, -1073.
To determine if a subset of these 12 SNPs could account for most of the haplotypic diversity in these samples, we calculated entropy for all possible subsets of SNPs, increasing the number of SNPs in a subset from 1 to 12.
In Malawi seven SNPs must be included to represent 95% of the 12-SNP haplotypic diversity.
Our data are more consistent with previous reports of haplotypic structure where SNPs were ascertained by resequencing in a large sample of chromosomes [ 15 16 17 ] .
Even in the extreme case when linkage disequilibrium is at its theoretical maximum ( D ' = 100% and no recombination has occurred between the two SNPs), the relative risk at the marker locus will be some fraction of the relative risk at the disease susceptibility locus, unless the two alleles have the same frequency [ 19 ] . Using the relationship defined in Equation 2 (see Materials and methods), we can examine the haplotypic structure of a candidate locus and assess the ability of one marker to detect a disease association when a second marker contributes a given disease risk.