Words similar to granulomatous
Example sentences for: granulomatous
How can you use “granulomatous” in a sentence? Here are some example sentences to help you improve your vocabulary:
Lastly, Crohn's disease or ulcerative colitis with extraintestinal manifestations was a possibility with her severe iron deficiency anemia, diarrhea, and granulomatous enteritis.
Although Still's disease can rarely lead to hepatic involvement with cholestatic hepatitis, the prior history of rheumatoid factor seropositivity and a low serum ferritin level made this diagnosis unlikely [ 21 ] . Granulomatous hepatitis with marked elevations in serum alkaline phosphatase and granulomas on liver biopsy have been reported in patients with SSZ hepatotoxicity [ 22 23 24 ] . Although liver tissue was not obtained in our patient, the predominance of serum alkaline phosphatase and bilirubin level elevations and the presence of granulomas in other tissues suggest that she probably had granulomatous hepatitis.
Sulfasalazine (SSZ) is a widely used and highly effective anti-inflammatory agent in the treatment of Crohn's disease and ulcerative colitis [ 1 2 3 ] . SSZ is also being used with increasing frequency in the treatment of various rheumatolgical disorders [ 4 5 6 7 ] . SSZ is preferred over other agents such as gold and penicillamine in rheumatology patients due to its more favorable side effect profile [ 8 9 10 ] . Nonetheless, rash, fever, and dyspepsia occur in 3% to 20% of treated patients [ 7 11 12 ] . These reactions are usually dose dependent and improve with dose reduction or discontinuation [ 7 12 ] . However, more serious but less common side effects have also been reported [ 13 14 15 16 17 18 19 ] . We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.
To our knowledge, only one other case of a systemic granulomatous reaction to SSZ has been reported which improved within 24 hours of SSZ discontinuation [ 18 ] . In other cases of granulomatous drug reactions, multi-organ involvement with fevers and eosinophilia have been reported [ 19 20 ] .
Seizures have previously been reported in patients receiving SSZ, often in the setting of other clinical manifestations of toxicity [ 31 41 42 ] . Although a brain biopsy would be needed to prove our hypotheses, there is a precedent for other systemic granulomatous disorders such as sarcoidosis leading to CNS granuloma formation and seizures [ 43 44 ] . Fortunately, this patient has remained stable with no evidence of a progressive neurological disorder 7 months after presentation.
Loading...