Words similar to granulomatous
Example sentences for: granulomatous
How can you use “granulomatous” in a sentence? Here are some example sentences to help you improve your vocabulary:
In recent years Burkholderia cepacia has become the second leading cause of death in patients with chronic granulomatous disease (CGD).
Sulfasalazine (SSZ) is a widely used and highly effective anti-inflammatory agent in the treatment of Crohn's disease and ulcerative colitis [ 1 2 3 ] . SSZ is also being used with increasing frequency in the treatment of various rheumatolgical disorders [ 4 5 6 7 ] . SSZ is preferred over other agents such as gold and penicillamine in rheumatology patients due to its more favorable side effect profile [ 8 9 10 ] . Nonetheless, rash, fever, and dyspepsia occur in 3% to 20% of treated patients [ 7 11 12 ] . These reactions are usually dose dependent and improve with dose reduction or discontinuation [ 7 12 ] . However, more serious but less common side effects have also been reported [ 13 14 15 16 17 18 19 ] . We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.
Although rheumatology patients may be at increased risk of SSZ toxicity compared to IBD patients, there are no reliable laboratory or clinical predictors of SSZ toxicity [ 45 ] . Therefore, practicing physicians should be aware of the potential for severe, unexplained granulomatous reactions to SSZ that can mimic other infectious, malignant, and autoimmune conditions.
The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease of childhood, is a rare familial granulomatous disease [ 1 ] . Affected individuals typically display one or more of the following granulomatous inflammations that have variable age-at-onset: acute anterior uveitis, arthritis, and skin rash.
Seizures have previously been reported in patients receiving SSZ, often in the setting of other clinical manifestations of toxicity [ 31 41 42 ] . Although a brain biopsy would be needed to prove our hypotheses, there is a precedent for other systemic granulomatous disorders such as sarcoidosis leading to CNS granuloma formation and seizures [ 43 44 ] . Fortunately, this patient has remained stable with no evidence of a progressive neurological disorder 7 months after presentation.
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