Words similar to granulation
Example sentences for: granulation
How can you use “granulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cellular FN is abundantly present in granulation tissue, is produced primarily by the wound fibroblasts and myofibroblasts.
Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
Thus, we conclude that SPARC deficiency compromises granulation tissue formation that involves fibroblast ingrowth and ECM protein deposition.
In the granulation tissue of burn wounds, expression of groα /MGSA and CXCR2 (the receptor for MGSA) was associated with fibroblasts, smooth muscle cells/myofibroblasts and a subpopulation of macrophages [ 7 ] . Groα/MGSA and IL-8 have also been shown to enhance re-epithelialization of human skin grafts in chimeric mice [ 29 38 ] . It has also been found that several CXC chemokines can modulate angiogenesis [ 39 ] , a process that is critical for proper healing.
If similar behavior is seen in human chemokines, it could be a promising target in designing drugs that promote formation of granulation tissue in poorly healing wounds without causing excess scarring.
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