Words similar to granulation
Example sentences for: granulation
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TGFβ1 also supports the differentiation of fibroblasts into myofibroblasts, which are a major constituent of the granulation tissue [ 23 24 ] . The process depends upon the deformability of the ECM [ 17 25 ] and is mediated by the ED-A splice variant of fibronectin [ 26 27 ] . ED-A fibronectin is expressed in the initial stages of wound healing and along with collagen I is positively regulated by TGFβ1 [ 26 ] .
At day 4 reepithelialization and granulation tissue growth had begun as shown in the 6 mm biopsies in figure 1B.
At day 6, reepithelialization and granulation tissue formation appeared as elaborate in SPARC-null mice as in wild-type mice with the neoepidermis and granulation tissue filling two third of the wound beds (not shown).
Histological examination and study of the expression patterns of ECM components, fibronectin and type I collagen, at the wound site suggested that retarded granulation tissue formation caused impaired wound repair.
We have previously determined, using dose-dependent studies, that this concentration is optimal for functions of this chemokine on these embryonic fibroblasts and in processes of granulation tissue formation [ 3 4 ] ). Although chemokine concentrations of 10 -2-10 ng/ml can chemoattract and activate leukocytes, chemokines acting on other cell types such as endothelial cells, smooth muscle cells and fibroblasts require concentrations in the range of 10 2ng/ml and higher [ 4 26 27 28 ] . This is within physiological range; for example wound fluid from burn patients contain MGSA (a chemokine that is highly homologous to cCAF) concentrations of 10 2-10 3ng/ml [ 29 ] . Because both the N-terminal and C-terminal peptides of cCAF have been shown to be functional in culture and in vivo (1-4, 30), we also tested these two peptides (Fig.
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