Words similar to granulocyte
Example sentences for: granulocyte
How can you use “granulocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
One involved identification of a non-peptide activator of the granulocyte colony-stimulating factor (GCSF) pathway that appeared to act via receptor oligomerization [ 18 ] . Another report described a small-molecule activator of the insulin-signaling pathway that also acts at the level of the receptor [ 19 ] .
The purity of the granulocyte preparation and the neutrophil content was assessed by immunocytochemistry using DIFF quick staining according to the manufacturer's protocol (American Scientific Products, McGraw Park, IL).
Filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) has been shown to reduce the depth of the nadir ANC, shorten the duration of neutropenia, and reduce the risk of febrile neutropenia [ 3 ] , thereby maintaining chemotherapy dose [ 4 5 ] . Many patients with early-stage breast cancer do not receive the full chemotherapy dose intensity recommended in conventional adjuvant chemotherapy regimens [ 6 7 8 ] . Neutropenia is the primary reason for chemotherapy dose delays and reductions [ 1 6 7 ] .
The reduction of glucose levels to below 200 mg/dl has been shown to improve granulocyte adherence and granulocytosis, both key components of the innate immunity and the defense against bacterial infections.
In this regard, recent studies have shown that inflammatory mediators such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor and leukotriene B 4 delay apoptosis and prolong neutrophil survival in culture [ 3 4 ] . Neutrophils migrating into rodent lungs in response to LPS challenge have also been reported to exhibit delayed rates of apoptosis [ 5 6 ] . Similarly, increases in cytokine and growth factor activity, and reduced neutrophil apoptosis, have been described in various inflammatory lung diseases in humans including chronic obstructive pulmonary disease, acute respiratory distress syndrome and pneumonia [ 3 7 8 ] .
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