Words similar to dpc
Example sentences for: dpc
How can you use “dpc” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
5 dpc, into a superficial half, enriched in the superficial fetal components, and a deeper half, enriched in deep fetal and superficial maternal components, and extracted RNA from each half.
This pathway seems to be required for full TGFβ 1 induced transcriptional activation, which explains the TGFβ 1 sensitivity of those cells lacking DPC4/SMAD4 function that still react with growth inhibition.
5 dpc, after these layers have begun to mature (Fig.
In several cell lines, particularly in pancreatic carcinoma cells, resistance to TGFβ 1 could be attributed to a loss of function of the SMAD4 (DPC4) protein [ 40 41 42 43 ] . However, the pancreatic carcinoma cell line BxPC-3, although homozygously deleted for SMAD4, is growth inhibited by TGFβ 1 [ 30 44 ] . It is thus speculated that alternative signaling pathways in addition to the SMAD pathway may exist.
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