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Example sentences for: dpbbs

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Furthermore, the SBHM also contributes to the stabilization of the catalytic site by forming an interface between the two DPBBs (Fig.
This arrangement suggests that the primordial RNA polymerase was a head to tail homodimer of a DPBB domain; a duplication of this primordial DPBB domain probably gave rise to the two DPBBs of modern DDRPs.
The psi-loops between strands 1 and 2 and between strands 4 and 5 often harbor the active site or substrate-interaction residues of the respective DPBBs.
Of these, the small residues preceding strands 3 and 6 contribute a positive φ angle, which results in turning of the C-α backbone to stabilize the β-barrel [ 62 ] . These shared features notwithstanding, the ancient DPBBs have no conserved residues in their catalytic or substrate-binding sites.
In contrast, the DPBBs detected in DDRP subunits are universally present in all modern life forms and hence are traceable to LUCA.