Words similar to dpbb
Example sentences for: dpbb
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Sequence comparisons and identification of specific conserved motifs showed that the DPBB fold includes five major superfamilies.
The basic DPBB fold consists of six β-strands and two variable regions, which are located after strand 2 and strand 5 and, at least in some case, adopt a helical conformation [ 62 63 64 ] . The domain can be further split into two symmetrical structural units, each with three core β-strands.
The predicted DPBB domains of the RDRPs differ from most of the DPBB domains of DDRP β' subunits in that the former lack a long and variable, in both length and sequence, insert between strands 2 and 3 that is characteristic of the latter (Fig.
The DPBB domain in the β subunit is distorted by large inserts and shares no detectable sequence similarity with the DPBB from the β' subunit.
Evidence is presented that the ultimate ancestor of RNA polymerases might have been a RNA-binding DPBB domain, which functioned as a cofactor for a polymerase ribozyme, and that subsequent evolution of DDRPs and RDRPs proceeded via accretion of various simple modules, such as the sandwich-barrel hybrid motif domain, around this conserved core.