Words similar to dpab
Example sentences for: dpab
How can you use “dpab” in a sentence? Here are some example sentences to help you improve your vocabulary:
Therefore, though low levels of ALDH1A1 activity have been reported in HL-60 cells in previous studies [ 5 31 ] , it appears that the differentiation observed in cells exposed to retinal alone or retinal plus DPAB was not mediated by ALDH1A1 oxidation of retinal to retinoic acid.
Since DPAB's inhibition of cell differentiation in cells exposed to retinal was so low, we needed to demonstrate that chemical oxidation or any serum enzymatic oxidation of retinal to retinoic acid was not occuring under our culture conditions.
In addition, the NAD-dependent oxidation of propanal or retinal was less than 0.05 nmoles NADH formed/min-10 7cells in spectrophotometric assays using HL-60 cell extracts, even in the absence of DEAB or DPAB.
In this paper we show that DPAB is a potent inhibitor of retinal oxidation by murine and human ALDH1A1.
Treatment of L1210/CPA cells in vitro with 50 μM DEAB abolished the tumor cells' resistance to 4-HC [ 19 ] . DEAB also exhibited in vivo efficacy as a ALDH1A1 inhibitor, as demonstrated by the toxicity to the intestinal crypt cells in mice receiving co-injections of DEAB and cyclophosphamide [ 21 ] . More recently, DEAB has been used to demonstrate that overexpression of human ALDH1A1 in transfected cell lines is sufficient to cause cellular resistance to the oxazaphosphorines [ 22 ] and 4-HC [ 23 ] . DEAB has also been an effective reagent in fluorescent-activated cell sorting (FACS) techniques to isolate human hematopoietic stem cells based on the expression of ALDH1A1 activity [ 5 6 ] . In contrast to DEAB and DPAB, daidzin - a natural product isolated from Pueraria lobata (the Kudzu plant) - shows specificity for inhibiting ALDH2 at concentrations similar to that of DPAB used to inhibit ALDH1A1 [ 24 25 ] . An inhibitor specific for ALDH1A2 has not yet been reported.
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