Example sentences for: downregulated

How can you use “downregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As a direct consequence of SKP2 downregulation, p27 is upregulated and cyclin A is downregulated.

  • Thus, E2F is downregulated in advance of significant BrdU incorporation in wild-type wing disc cells.

  • At 4 h after challenge, the highest number of downregulated cDNA elements (92) was observed, while the highest number of upregulated cDNA elements (51) was seen in the IL-4-challenged monkey.

  • Spearman's rank order correlation determined significant monotonic relationships that illuminate important connections between structural features in tissue elements and genes that have been reported as significantly up- or downregulated by CCl 4 treatment in previous studies [ 7 ] . Principal component analysis (PCA), as described in Materials and methods, was carried out to reduce the complexity of the data [ 15 ] and then to relate individual animals to specific phenotypic groups.

  • The remaining two significantly regulated genes (for orphan nuclear hormone receptor BD73 and pepsinogen C) were initially identified as downregulated by greater than fourfold.


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