Words similar to downregulated
Example sentences for: downregulated
How can you use “downregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [ 6 7 ] . In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [ 3 ] ) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [ 6 8 9 ] , provided that at least some differentiation of supporting cells takes place.
Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.
This experiment likely overestimates p27 half-life in untreated cells, as SKP2 was itself downregulated by CHX (data not shown).
Thus, it is interesting to speculate that IL-2 and IL-4 are downregulated in the rheumatoid synovium by some active repressor mechanism induced by the synovial microenvironment.
However, those investigators did not observe any difference in plasma NO metabolites in normoxic versus hypoxic rats in which aortic NOS was downregulated, but did observe a decrease in acetylcholine-stimulated NO release from aortic rings.
Loading...