Example sentences for: downregulated

How can you use “downregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [ 6 7 ] . In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [ 3 ] ) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [ 6 8 9 ] , provided that at least some differentiation of supporting cells takes place.

  • Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.

  • This experiment likely overestimates p27 half-life in untreated cells, as SKP2 was itself downregulated by CHX (data not shown).

  • Thus, it is interesting to speculate that IL-2 and IL-4 are downregulated in the rheumatoid synovium by some active repressor mechanism induced by the synovial microenvironment.

  • However, those investigators did not observe any difference in plasma NO metabolites in normoxic versus hypoxic rats in which aortic NOS was downregulated, but did observe a decrease in acetylcholine-stimulated NO release from aortic rings.


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