Words similar to downregulates

Example sentences for: downregulates

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A role for BMP-5 in dorsal forebrain patterning has been proposed based on its expression in the dorsal midline of the developing forebrain and observations that ectopic expression of BMP-5 in the developing neural tube of chicks markedly downregulates ventral markers while maintaining dorsal markers [ 5 7 ] . Further support for BMP-5 regulation of early forebrain development has been provided by studies of Bmp5/Bmp7 double mutants [ 6 ] . However, reports that BMP-5 in the mouse brain exhibits peak expression levels in the adult striatum and brainstem and that maximal expression in the hippocampus and cerebellum occurs at E18 through PN1 and again in the mature nervous system [ 3 ] , suggest additional roles for BMP-5 during later stages of neural development and into adulthood.
This raises the question of how RA initially downregulates cyclin H and cdk7 expression, whether by AP-1 inhibition or through negative retinoid response elements in the regulatory regions of the genes.
They block the glutamatergic (excitatory) pathways that are overstimulated in PD [ 7 ] . Such action decreases the influx of calcium ions into the neuron, and hence downregulates the activation of calcium dependent enzymes.
This might be especially pertinent if the host downregulates the endogenous ortholog in response to the infection.
The SH2 domain-containing inositol phosphatase (SHIP) downregulates Btk by dephosphorylating PIP3 [ 4, 5, 6].