Words similar to downregulates
Example sentences for: downregulates
How can you use “downregulates” in a sentence? Here are some example sentences to help you improve your vocabulary:
This might be especially pertinent if the host downregulates the endogenous ortholog in response to the infection.
They block the glutamatergic (excitatory) pathways that are overstimulated in PD [ 7 ] . Such action decreases the influx of calcium ions into the neuron, and hence downregulates the activation of calcium dependent enzymes.
The SH2 domain-containing inositol phosphatase (SHIP) downregulates Btk by dephosphorylating PIP3 [ 4, 5, 6].
[ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .
This raises the question of how RA initially downregulates cyclin H and cdk7 expression, whether by AP-1 inhibition or through negative retinoid response elements in the regulatory regions of the genes.
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