Words similar to downregulation

Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

Ese-1/Esx is a member of the Ets transcription factor family and is expressed mainly in epithelial tissue [ 30 ] . Its expression has been detected during mammary gland development and breast tumorigenesis [ 47 48 ] . It is noteworthy that Ese-1/Esx is a potential transcriptional regulator of the TGFβ type II receptor [ 31 ] and overexpression of Ese-1/Esx in non-invasive cells leads to a reduction in cell growth in the presence of TGFβ, presumably because of an increased TGFβ type II receptor level [ 49 ] . It is interesting that TGFβ-dependent downregulation of Ese-1/Esx is not affected by SB-203580.
It is remarkable that a constitutively active form of JNK activator MKK and Smad7 are able to cooperatively downregulate TGFβ-responsive promoters [ 53 ] . It is quite possible that a Smad7/JNK synergistic interaction is involved in the TGFβ-dependent downregulation of Ese-1/Esx expression, where JNK alone might mediate the initiation of the TGFβ-induced repression.
Therefore, migration into tissue per se does not induce downregulation of IL-2 production.
The mutant version (C1684T, Arg554 → Trp; Figure 7a) of SDHA has a normal K m and K i (for malonate) but is much more sensitive to downregulation by oxaloacetate (OAA).
Because a high level of ectopic expression of E2F is known to induce apoptosis [ 12 ] [ 13 ] , these results suggest that mCul1 overexpression might interfere with normal E2F downregulation.