Words similar to downregulation
Example sentences for: downregulation
How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Over-expression of homeodomain-interacting protein kinase 2 (HIPK2), which increases p53 protein expression and/or stability, leads to a downregulation of mdm2 protein, but not mRNA [ 29 ] . Consequently, the RU486-induced increase in mdm2 mRNA expression, coupled with a decrease in that of P53, may also act in tandem to suppress the liver apoptotic capacity (Fig 1B).
The WHR, a measure of central adiposity, is gaining increased use as a measure of etiologically significant obesity and is thought to be more closely related to pathology, especially coronary heart disease, diabetes mellitus and stroke [ 7 ] . The metabolic changes that accompany obesity include peripheral hyperinsulinemia, hyperglycemia and glucose intolerance, hypertriglyceridemia, decreased serum low-density lipoprotein, increased serum very low-density lipoprotein, increased serum leptin, dyslipidemia, increased serum cortisol clearance, increased serum C-peptide level, downregulation of insulin receptors and an exaggerated insulin response to an oral glucose load [ 12 13 14 15 ] . These changes, especially when they occur in early adulthood, may be of fundamental importance in the development of breast cancer [ 9 16 ] .
For example, in the related Rip1-Tag5 model, the vascular addressins GlyCAM-1 and MAdCAM-1 are expressed in pre-malignant islets, but down-regulated in solid tumors; their downregulation coincides with lack of infiltration in this model of spontaneous anti-tumor immunity [ 19 ] . It is possible that sub-lethal radiation is altering the expression of endothelial adhesion molecules allowing binding and extravasation of activated tumor-specific lymphocytes.
[ 38] reported in vivo downregulation of eNOS mRNA and protein levels in the aorta of rats following prolonged hypoxia, which correlated with impaired endothelium-dependent vasorelaxation, whereas there was an increase in eNOS protein levels in the lungs.
Because a high level of ectopic expression of E2F is known to induce apoptosis [ 12 ] [ 13 ] , these results suggest that mCul1 overexpression might interfere with normal E2F downregulation.
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