Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our data suggest that androgen-mediated SKP2 downregulation is responsible for decreased ubiquitylation and accumulation of p27 in LNCaP cells, an effect that is readily overcome by overexpression of SKP2.

  • This reduction in antibody levels may be a direct effect on B cells due to a loss of IL-10 or may be an indirect effect due to downregulation by IFN-γ.

  • Infection of asynchronous LNCaP cells with SKP2 virus led to time-dependent downregulation of p27 (Fig.

  • 4C), we conclude that SKP2 directly triggers the ubiquitylation and degradation of p27 in LNCaP cells, a process which is attenuated by androgen-mediated SKP2 downregulation.

  • We propose that frequent p27 downregulation in prostate cancer may be caused by SKP2 overexpression thus enabling escape from normal androgen control.


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