Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Re-administration of androgen induces transient epithelial cell proliferation, presumably mediated by proteolytic downregulation of p27, until pre-castration cell numbers have been restored [ 48 49 ] . No further proliferation ensues beyond this point, at which p27 levels are increased again, despite the continuous presence of androgen.

  • This may contribute to the downregulation of cyclin D1 protein and is consistent with a previous report showing an increase in cyclin D1 mRNA in cells overexpressing eIF4E [ 26 ] .

  • A plethora of circumstantial evidence implicates downregulation of the cyclin-dependent kinase (CDK) inhibitor p27 in prostate cancer.

  • We show that androgen-induced p27 upregulation is paralleled by p27 stabilization and SKP2 downregulation.

  • The mutant version (C1684T, Arg554 → Trp; Figure 7a) of SDHA has a normal K m and K i (for malonate) but is much more sensitive to downregulation by oxaloacetate (OAA).


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