Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, downregulation of cyclin D1 leads to release of p27 Kip1sequestered by the cyclin D1/CDK4 complex.

  • In contrast, the tumors from patients with BRCA1 mutations appear to have downregulation of estrogen receptors [ 43, 44, 45].

  • The top 20 ranking genes can be seen in Figure 12, where the genes known to be differentially regulated are shown in parentheses and up- or downregulation is shown in red or green, respectively.

  • Northern blot analysis revealed that MIB-induced SKP2 downregulation at the protein level is reflected by quantitatively similar changes in steady state RNA levels (Fig 3A).

  • Infection of asynchronous LNCaP cells with SKP2 virus led to time-dependent downregulation of p27 (Fig.


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