Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We therefore asked whether SKP2-mediated p27 downregulation in MIB arrested LNCaP cells was able to actually bring about CDK2 activation.

  • As a direct consequence of SKP2 downregulation, p27 is upregulated and cyclin A is downregulated.

  • These results indicate that downregulation of PLD2 activity by antisense oligomers in SN56 cells decreases not only the endogenous PLD2 activity but also the intracellular choline and ACh content.

  • To determine whether SKP2 downregulation is a necessary step in MIB-induced p27 upregulation, LNCaP cells were blocked with MIB for 72 h, followed by infection with Ad-SKP2 or Ad-SKP2-ΔF for various periods.

  • This may contribute to the downregulation of cyclin D1 protein and is consistent with a previous report showing an increase in cyclin D1 mRNA in cells overexpressing eIF4E [ 26 ] .


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