Example sentences for: downregulation

How can you use “downregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This may contribute to the downregulation of cyclin D1 protein and is consistent with a previous report showing an increase in cyclin D1 mRNA in cells overexpressing eIF4E [ 26 ] .

  • Expression of 4EBP-1-5A results in enhanced p27 Kip1expression and downregulation of cyclin D1

  • First, downregulation of cyclin D1 leads to release of p27 Kip1sequestered by the cyclin D1/CDK4 complex.

  • We propose that frequent p27 downregulation in prostate cancer may be caused by SKP2 overexpression thus enabling escape from normal androgen control.

  • 41) at a time when p27 downregulation was already apparent (24 h), the majority of cells remained tightly arrested in G1 over the entire 72 h course of the experiment (Fig.


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