Example sentences for: downregulate

How can you use “downregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To date, numerous experiments in animal models suggest RNAi can downregulate a variety of target genes effectively.

  • This indicates that, in flies, precursors express Delta and that those specified for neuroblast development downregulate its expression.

  • In accord with these results, flavopiridol treatment was recently shown to downregulate two of these anti-apoptotic proteins, MCL1 and Bag-1, and induce apoptosis in B-CLL cells treated with flavopiridol [ 29].

  • It is remarkable that a constitutively active form of JNK activator MKK and Smad7 are able to cooperatively downregulate TGFβ-responsive promoters [ 53 ] . It is quite possible that a Smad7/JNK synergistic interaction is involved in the TGFβ-dependent downregulation of Ese-1/Esx expression, where JNK alone might mediate the initiation of the TGFβ-induced repression.

  • The reduction in SCF function associated with mCul1 overexpression also correlated with a failure to downregulate E2F normally in S phase.


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