Example sentences for: downregulate

How can you use “downregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The reduction in SCF function associated with mCul1 overexpression also correlated with a failure to downregulate E2F normally in S phase.

  • In accord with these results, flavopiridol treatment was recently shown to downregulate two of these anti-apoptotic proteins, MCL1 and Bag-1, and induce apoptosis in B-CLL cells treated with flavopiridol [ 29].

  • IL-4 can downregulate the production of proinflammatory and T-helper (Th)1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1 receptor antagonist (IL-1Ra) [ 3, 4].

  • Currently, we cannot distinguish between the possibilities that alternating cells downregulate isl1 expression or that cells that do not express isl1 move between those that do.

  • Immunoblotting revealed that SKP2 overexpression can efficiently downregulate p27 levels in the continuous presence of MIB (Fig.


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