Example sentences for: downregulate

How can you use “downregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is remarkable that a constitutively active form of JNK activator MKK and Smad7 are able to cooperatively downregulate TGFβ-responsive promoters [ 53 ] . It is quite possible that a Smad7/JNK synergistic interaction is involved in the TGFβ-dependent downregulation of Ese-1/Esx expression, where JNK alone might mediate the initiation of the TGFβ-induced repression.

  • IL-4 can downregulate the production of proinflammatory and T-helper (Th)1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1 receptor antagonist (IL-1Ra) [ 3, 4].

  • Currently, we cannot distinguish between the possibilities that alternating cells downregulate isl1 expression or that cells that do not express isl1 move between those that do.

  • In accord with these results, flavopiridol treatment was recently shown to downregulate two of these anti-apoptotic proteins, MCL1 and Bag-1, and induce apoptosis in B-CLL cells treated with flavopiridol [ 29].

  • Thus it appears that a relatively small number of genes is downregulated by stress and suggests that different kinds of stress downregulate the same genes.


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