Words similar to downregulating
Example sentences for: downregulating
How can you use “downregulating” in a sentence? Here are some example sentences to help you improve your vocabulary:
Enhanced expression of c-jun, c-fos, p21 WAF1and p27 KIP, while downregulating PCNA, is dependent on ERK1/2 signaling, an intact cytoskeleton and intracellular calcium (Figures 5, 6A, 7, 8and additional files 6, 7and 8).
Previous work has suggested that although SERCA expression in limb muscles seems to respond to increases in functional load by upregulating SERCA 2 (the slow SERCA isoform) and downregulating SERCA 1 (the fast isoform) [ 50 ] , similar responses might not occur in diaphragm [ 51 ] . Our data showing no difference in the expression of SERCA 1 and SERCA 2 between emphysematous and control animals are consistent with this finding.
Second, it provides a means for researchers to test gene functions by experimentally downregulating expression of specific genes under well controlled conditions.
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.
These data suggest that SB-202190 and SB-203580 inhibit TGFβ-stimulated gene expression at least in part by downregulating transcription.
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