Example sentences for: dephosphorylation

How can you use “dephosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The recombinant full length and deletion mutants of human NFATp used in the studies described here as well as the methods that we have developed will be valuable for future biochemical studies of the function of NFATp in DNA binding, transcriptional activation, phosphorylation/dephosphorylation, and nuclear association.

  • Dephosphorylation was kept to less than 10 % of the total phosphorylated substrate, and the reaction was linear with respect to enzyme concentration and time.

  • Thus there is interest in using this class of inhibitors for chemotherapeutic treatment of cancer and several phase I trials have been carried out [ 22 ] . Treatment of mammalian cells with rapamycin leads to dephosphorylation and activation of 4EBP, which in turn binds to and inhibits eIF4E.

  • These data indicate that the v-crk SH2 domain interacts with the C-terminal YDXP motifs, and as suggested by Birge et al, v-crk may be able to protect them from dephosphorylation and/or induces their phosphorylation [ 12 ] . They also suggest that the YQXP motifs may be involved in binding to other intracellular signaling molecules.

  • The assembly of myosin II monomers into filaments is regulated by phosphorylation of its heavy chains at three threonine residues at the C-terminus of the tail [ 9 10 ] . Dephosphorylation of these threonines is a prerequisite of filament assembly, as confirmed by the phenotypes of a 3xAsp mutant, in which the three threonines are replaced by three aspartate residues (mimicking the phosphorylated state) [ 11 ] . In vitro the 3xAsp myosin II is severely impaired for filament assembly, and in vivo 3xAsp myosin II fails to assemble or localize to the cortical cytoskeleton.

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