Words similar to dephosphorylation
Example sentences for: dephosphorylation
How can you use “dephosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cells were lysed in a phosphate lysis buffer to prevent protein dephosphorylation (200 mM sodium phosphate, pH 7.5, 20 mM KCl, 5% sucrose, 0.5% NP-40, 1 mM PMSF).
One of the established in vivo substrates of PTEN, FAK, is known to play a major role in growth-regulatory signal transduction initiated by cell surface integrin receptors [ 48 49 ] . As we observe a correlation between increased PTEN activity and decreased levels of FAK phosphorylation (compare Figure 4Band Figure 5), it is likely that the dephosphorylation of FAK in response to the disruption of cell-matrix interactions is accomplished by increased PTEN activity.
We have also shown that recombinant NFATp purified from insect cells is a phosphoprotein that exhibits association with nuclei in vitro only after dephosphorylation by calcineurin.
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
Like PP5, the dephosphorylation of 32P-MBP by Ppt1p was stimulated by arachidonic acid and other unsaturated fatty acids, but lipids lacking either a double bond or a carboxylate group were not effective (Table 1).
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