Example sentences for: dephosphorylated

How can you use “dephosphorylated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When T cells are stimulated, NFATp is dephosphorylated by calcineurin and it migrates farther on SDS gels than its phosphorylated counterpart.

  • To examine whether the p44/42 MAPK pathway mediates insulin signaling in the H441 cells, PD98059, an inhibitor of the p44/42 MAPK pathway, was used [ 9 ] . PD98059 binds to the dephosphorylated form of MEK and prevents its activation in vivo with an IC 50 of 10 μM [ 9 ] . PD98059, added alone, significantly decreased SP-A mRNA levels in a dose-dependent manner (Fig.

  • We first determined the effect of SKP2 overexpression on MIB-induced RB1 downregulation and accumulation in the dephosphorylated state (see Fig.

  • The resulting vector was digested with EcoRI, dephosphorylated with calf intestinal phosphatase (CIP, NEB), and a PCR product generated from pVT27 (Abedi et.

  • In another report, micro-injection of PP1 decreased extractability of pRB from nuclei, presumably by increasing dephosphorylation and increasing association with nuclear proteins thereby playing a role in G1/S transition inhibition [ 13 ] . Micro-injection of antibodies to the PP1 catalytic subunit has been shown to block cells in metaphase [ 23 ] . Since this is the time during mitosis when pRB is normally dephosphorylated [ 11 24 ] , it is tempting to speculate that prevention of pRB dephosphorylation by inhibiting PP1 activity impedes an orderly progression through mitosis, perhaps contributing towards a transformed phenotype.


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