Example sentences for: dephosphorylating

How can you use “dephosphorylating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The SH2 domain-containing inositol phosphatase (SHIP) downregulates Btk by dephosphorylating PIP3 [ 4, 5, 6].

  • The gene product of PTEN ( phosphatase and tensin homolog deleted from chromosome 10) is a lipid phosphatase that reverses the activities of phosphatidylinositol 3-kinase (PI3K) by dephosphorylating the D3 position of its lipid products, phosphatidylinositol-3, 4 bis-phosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5 bis-phosphate (PtdIns(3,5)P2), and 3,4,5-tri-phosphate (PtdIns(3,4,5)P3) [ 2, 3], the elevated levels of which are linked to the transforming ability of PI3K [reviewed in ref.

  • In addition, the SH3 domain of Cas mediates an interaction with FAK, C3G, CMS, and the zinc finger containing protein CIZ, while nephrocystin interacts with Cas via its SH3 domain and proline rich sequences in Cas [ 24 25 26 27 28 29 30 ] . The SH3 domain of Cas can also interact with the tyrosine phosphatase PTP1B, and expression of PTP1B in transformed cells reverts the phenotype, in part by dephosphorylating Cas [ 31 32 ] .


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