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Example sentences for: dazl

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The expression of DAZAP1 during germ cell development paralleled that of DAZL (Figure 5).
Deletion of the DAZ genes is found in about 10% of infertile males with idiopathic azoospermia [ 2 ] , and disruption of Dazl1 causes infertility in both male and female mice [ 6 ] . Mutations in the DAZ family members of Drosophila [ 7 ] , C. elegans [ 8 ] , and Xenopus [ 9 ] also affect the fertility in either males, females, or both sexes.
The expression of both Dazl1 and Dazap1 persisted throughout testes development, in both the prenatal and postnatal periods.
Drosophila Boule mutants was defective in the translation of the meiosis-specific CDC25 homologue, Twine [ 11 ] , and DAZL was found to be associated with polyribosomes in mouse testes [ 12 ] . More recently, DAZL was shown both in vitro and in a yeast three-hybrid system to bind specifically to oligo(U) stretches interspersed by G or C residues, including a U-rich segment in the 5' UTR of mouse Cdc25C mRNA [ 13 ] .
Dazl1 and Dazap1 transcripts were also present in the testes of W v/W vmutant mice which contained diminished number of germ cells [ 18 ] . However, only Dazap1 was expressed in a mouse germ cell line GCl-spg [ 19 ] and a Sertoli cell line MT4.