Example sentences for: dazl

How can you use “dazl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Drosophila Boule mutants was defective in the translation of the meiosis-specific CDC25 homologue, Twine [ 11 ] , and DAZL was found to be associated with polyribosomes in mouse testes [ 12 ] . More recently, DAZL was shown both in vitro and in a yeast three-hybrid system to bind specifically to oligo(U) stretches interspersed by G or C residues, including a U-rich segment in the 5' UTR of mouse Cdc25C mRNA [ 13 ] .

  • Nova-1 regulates the alternative splicing of the pre-mRNAs encoding neuronal inhibitory glycine receptor α2 (GlyR α2) [ 23 ] . The ability of Nova-1 to activate exon selection in neurons is antagonized by a second RNA-binding protein, brPTB (brain-enriched polypyrimidine tract-binding protein), which interacts with Nova-1 and inhibits its function [ 24 ] . DAZAP1 could function in a similar manner by binding to DAZL and inhibiting its function.

  • Dazl1 knock-out mice have already been generated and studied [ 6 ] . The spermatogenic defect in the male becomes apparent only after day 7 post partum when the germ cells are committing to meiosis (H.

  • Dazl1 and Dazap1 transcripts were also present in the testes of W v/W vmutant mice which contained diminished number of germ cells [ 18 ] . However, only Dazap1 was expressed in a mouse germ cell line GCl-spg [ 19 ] and a Sertoli cell line MT4.

  • RNA-binding proteins have been found to participate in many cellular functions, including RNA transcription, pre-mRNA processing, mRNA transport, localization, translation and stability [ 20 ] . A role for the DAZ family in the regulation of mRNA translation is supported by lines of circumstantial evidence, including the association of DAZL with polyribosomes [ 12 ] . The absence of DAZAP1 from polyribosomes indicates that it is not directly involved in protein synthesis.


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